{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:55:35Z","timestamp":1761540935431,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)\/antigen (Ag) ratios &lt;0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)\/VWF:Ag ratio is normal in VWD 2M. Typical laboratory features of VWD type 2 M are decreased ristocetin-induced platelet aggregation in the presence of a normal or near normal VWF multimeric pattern on a low-resolution agarose gel, a poor response to desmopressin (DDAVP) of VWF:RCo, and a good response of both VWF:CB and VWF:Ag to DDAVP. The phenotypic definition of VWD type 2M may need to be more stringent and should be the subject of an international standardization initiative.<\/jats:p>","DOI":"10.1159\/000214854","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T19:04:37Z","timestamp":1244228677000},"page":"139-144","source":"Crossref","is-referenced-by-count":7,"title":["Autosomal Dominant von Willebrand Disease Type 2M"],"prefix":"10.1159","volume":"121","author":[{"given":"Cedric","family":"Hermans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Batlle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2006.02146.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fbeha.2001.0137"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.thromres.2007.03.014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-05-021105."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-05-020784"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.20470"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1067%2Fmlc.2001.111252"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.1983.tb02165.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fbeha.2001.0134"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177%2F1076029606293422"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2002.03199.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-06-2072"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2007.02853.x"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:27:08Z","timestamp":1745447228000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":13,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000214854","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2009]]}}}