{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:22:23Z","timestamp":1777929743523,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Die Proliferation von Tumorzellen wurde durch Applikation oder Inkubation mit xenogenen Leberpr\u00e4parationen in vivo und in vitro gehemmt. Prophylaktische Injektionen dieser Pr\u00e4parate hemmten die Entwicklung subkutaner implantierter Meth-A-Sarkome. Dar\u00fcber hinaus konnten etablierte Tumoren durch Therapie zur Regression gebracht werden. Pr\u00e4parationen aus anderen xenogenen Organen wie Thymus, Plazenta und Hirn hatten eine \u00e4hnliche Wirksamkeit. Besonders effektiv war eine Mischung aus verschiedenen xenogenen Materialien. Die antitumorale Wirkung von noch tolerierbaren Dosen von Cyclophosphamid konnte im untersuchten Meth-A-Sarkom \u00fcbertroffen werden. Die Pr\u00e4parationen waren in Maus und Ratte nebenwirkungsfrei. Diese Befunde konnten durch Ergebnisse in der Gewebe-kultur an humanen Tumorzellen gest\u00fctzt und erweitert werden. Diese neuartige, antitumorale Wirkung xenogener Gewebe in vivo wird als eine Verst\u00e4rkung der k\u00f6rpereigenen Abwehr interpretiert. Die Ergebnisse der Gewebekultur sprechen aber auch f\u00fcr einen direkten regulativen Effekt auf die Zelle.<\/jats:p>","DOI":"10.1159\/000214976","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T10:40:22Z","timestamp":1240396822000},"page":"98-104","source":"Crossref","is-referenced-by-count":2,"title":["Antitumorale Wirkung xenogener Substanzen in vivo und in vitro"],"prefix":"10.1159","author":[{"given":"P.G.","family":"Munder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Stiefel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.H.","family":"Widmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Theurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,21]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000214976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:52:34Z","timestamp":1777679554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000214976","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}