{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:22:40Z","timestamp":1777929760398,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>10 Patienten mit Haarzell-Leuk\u00e4mie wurden in den Jahren 1972 bis 1981 in der Medizinischen Universit\u00e4tsklinik K\u00f6ln beobachtet, was 1,8% der Leuk\u00e4mie-Patienten entspricht. Dabei fand sich als typische Symptomenkonstellation die deutliche Splenomegalie, fehlende oder nur m\u00e4\u00dfig vergr\u00f6\u00dferte Lymphknoten sowie eine leichte Hepatomegalie. Regelm\u00e4\u00dfig lie\u00dfen sich auch eine An\u00e4mie, eine Thrombopenie sowie eine Neutropenie mit Lymphozytose, meist kombiniert als Panzytopenie nachweisen. Die pathognomonische tartratresistente saure Phosphatase wurde in wechselndem Ausma\u00df in den Haarzellen neben einer Fibrosierung sowie einer lymphatischen Infiltration des Knochenmarks gefunden. Durch Splenektomie lie\u00df sich regelm\u00e4\u00dfig eine Normalisierung der An\u00e4mie, der Thrombopenie sowie der Neutropenie erzielen, die gesteigerte Infektanf\u00e4lligkeit konnte jedoch nicht wesentlich beeinflu\u00dft werden.<\/jats:p>","DOI":"10.1159\/000215006","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T10:40:22Z","timestamp":1240396822000},"page":"216-221","source":"Crossref","is-referenced-by-count":0,"title":["Klinik der Haarzell-Leuk\u00e4mie und ihre Beeinflussung durch Splenektomie"],"prefix":"10.1159","author":[{"given":"J.","family":"Rojo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.M.","family":"Gl\u00f6ckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,21]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000215006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:53:01Z","timestamp":1777679581000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000215006","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}