{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:22:50Z","timestamp":1777929770258,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Bei einem S\u00e4ugling und einem Kleinkind mit metastasiertem Neuroblastom konnten Chromosomen direkt aus Prim\u00e4rtumor und Knochenmarkmetastasen pr\u00e4pariert werden. Insgesamt 765 Tumormetaphasen konnten nach Giemsa-Bandenf\u00e4rbung gez\u00e4hlt und teilweise karyotypisiert werden. \u00bbDouble Minute\u00ab Chromosomen wurden in den Metaphasen sowohl des Prim\u00e4rtumors und der Metastasen bei dem S\u00e4ugling gefunden, aber nur im Prim\u00e4rtumor des anderen Kindes. Strukturell auff\u00e4llig neben anderen Translokationen war in beiden Fallen der kurze Arm von Chromosom Nr. 1. Die modale Chromosomenzahl betrug bei dem S\u00e4ugling 46 im Prim\u00e4rtumor und Knochenmark, bei dem Kleinkind 84 im Prim\u00e4rtumor und 46 und \u00fcber 100 im Knochenmark. Eine klonale Evolution der Neuroblastomzellen bei Metastasierung wird diskutiert.<\/jats:p>","DOI":"10.1159\/000215020","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T10:40:22Z","timestamp":1240396822000},"page":"268-272","source":"Crossref","is-referenced-by-count":1,"title":["Chromosomenuntersuchungen beim metastasierten Neuroblastom"],"prefix":"10.1159","author":[{"given":"F.","family":"Franke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lampert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,21]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000215020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:53:18Z","timestamp":1777679598000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000215020","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}