{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:23:09Z","timestamp":1777929789813,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>35 Patienten mit kleinzelligem Bronchialkarzinom wurden mit einer Chemotherapie nach dem ACO-Schema (Adriamycin, Cyclophospha-mid, Vincristin) behandelt. Zwischen der 3. und der 4. Chemotherapieserie wurde eine Bestrahlung der Prim\u00e4rtumorregion mit 50\u201360 Gy sowie der tumorfreien Anteile des Mediastinums und des Sch\u00e4dels mit 30 Gy durchgef\u00fchrt. Eine Vollremission erreichten 10 von 14 Patienten mit \u00bblimited disease\u00ab (71 %) und 6 von 21 Patienten mit \u00bbextensive disease\u00ab (29%). Die mediane \u00dcberlebenszeit war 13 Monate f\u00fcr Patientin mit LD und 7 Monate f\u00fcr solche mit ED. Rezidive traten meist au\u00dferhalb des Bestrahlungsfeldes auf oder gleichzeitig im bestrahlten Bereich und auch au\u00dferhalb davon. Nur bei 3 von 16 Patienten, die eine Vollremission erreichten, lag das Rezidiv prim\u00e4r im Bestrahlungsfeld. Gegen\u00fcber den Ergebnissen der kombinierten Chemo- und Radiotherapie mit Strahlendosen von nur 30\u201340 Gy im Bereich des Prim\u00e4rtumors war damit die lokale Tumorkontrolle verbessert ohne eine wesentliche \u00c4nderung der Remissionsrate oder der medianen \u00dcberlebenszeit. Die Toxizit\u00e4t war durch die hohe Strahlendosis nicht gesteigert.<\/jats:p>","DOI":"10.1159\/000215191","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T10:40:22Z","timestamp":1240396822000},"page":"22-25","source":"Crossref","is-referenced-by-count":0,"title":["Kombinierte Chemo- und Radiotherapie des kleinzelligen Bronchial-karzinoms mit Anwendung hoher Strahlendosen"],"prefix":"10.1159","author":[{"given":"B.","family":"Steinke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Voss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ostendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.D.","family":"Waller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,21]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000215191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:53:49Z","timestamp":1777679629000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000215191","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}