{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:23:09Z","timestamp":1777929789555,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Seit 1979 wurden in einer kooperativen Studie (COALL-80) 110 Kinder mit akuter lymphoblastischer Leuk\u00e4mie (ALL) und 13 Kinder mit hochgradig malignem non-Hodgkin-Lymphom (NHL) nach einer Modifikation der Westberliner Studie BFM 76\/79 mit verringerter Aggressivit\u00e4t behandelt. Dazu wurde Asparaginase aus der initialen Viermitteltherapie herausgenommen und zwischen die Initialphase und Behandlungsphase f\u00fcr das Zentralnervensystem (ZNS) eingef\u00fcgt. Die Durchf\u00fchrung der Initialphase gestaltete sich hierbei weitgehend unproblematisch und konnte in der Regel ambulant erfolgen. Die erwartete rezidivfreie \u00dcberlebenszeit f\u00fcr ALL nach \u00fcber 2\u00bd Jahren steht mit 86 % nicht hinter den Ergebnissen der urspr\u00fcnglichen BFM-Studie zur\u00fcck. Es gelang, in Abh\u00e4ngigkeit vom Lebensalter (&gt; 2, &lt; 7 Jahre), initialer Blastenzahl (&lt; 25000\/mm3) und immunologischer Typisierung [common ALL Antigen positiv (cALL Ag+)] eine gro\u00dfe Patientengruppe zu definieren (52 %), die bislang ohne R\u00fcckfall blieb. F\u00fcr sie ist ein weiterer Abbau der Behandlungsintensit\u00e4t [Verzicht auf Cyclophosphamid in der ZNS-Behandlungsphase, Ersatz der ZNS-Bestrahlung durch mittelhoch dosierte Methotrexatinfusionen (MTX-mHD)] in Zukunft geplant.)<\/jats:p>","DOI":"10.1159\/000215192","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T10:40:22Z","timestamp":1240396822000},"page":"26-32","source":"Crossref","is-referenced-by-count":1,"title":["Therapie der akuten Lymphoblastenleuk\u00e4mie im Kindesalter Multizentrische prospektive Therapiestudie COALL-80"],"prefix":"10.1159","author":[{"given":"K.","family":"Winkler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Beron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Th\u00f6ne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"J\u00fcrgens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gutjahr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-J.","family":"Spaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Drescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"M\u00fcller-Wickup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Landbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,21]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000215192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:53:49Z","timestamp":1777679629000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000215192","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}