{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:58:44Z","timestamp":1777946324848,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemostasis"],"abstract":"<jats:p>Desamino-D-arginine vasopressin (DDAVP) is known to stimulate factor VIII (FVIII) and plasminogen activator release from endothelial cells, and has been shown to stimulate prostacyclin (PGI&lt;sub&gt;2&lt;\/sub&gt;) production in normal and haemophilic subjects. In von Willebrand\u2019s disease (vWd) some patients have a dissociate response with regard to FVIII and plasminogen activator. The aim of our study was to compare the PGI&lt;sub&gt;2&lt;\/sub&gt;, FVIII and plasminogen activator response to DDAVP infusion in vWd with the response to DDAVP in normal and haemophilic subjects. PGI&lt;sub&gt;2&lt;\/sub&gt; metabolites thromboxane B&lt;sub&gt;2&lt;\/sub&gt; (TxB&lt;sub&gt;2&lt;\/sub&gt;), factor VIII coagulant activity, factor VIII-related antigen and plasminogen activator were measured before and after DDAVP infusion. There was a significant increase in PGI&lt;sub&gt;2&lt;\/sub&gt; metabolites, factor VIII-related antigen and plasminogen activator in all groups following DDAVP, but no effect on TxB&lt;sub&gt;2&lt;\/sub&gt; was found, and there was no evidence of any dissociate response to DDAVP in any of the groups. Basal levels of PGI&lt;sub&gt;2&lt;\/sub&gt; metabolites, however, were significantly lower in vWd as compared to normal and haemophilic subjects. Post-DDAVP levels of PGI&lt;sub&gt;2&lt;\/sub&gt; metabolites were also significantly lower in vWd as compared with normal subjects. This may be due to a reduced stimulus to PGI&lt;sub&gt;2&lt;\/sub&gt; production in vWd secondary to defective platelet adhesion.<\/jats:p>","DOI":"10.1159\/000215264","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T10:40:22Z","timestamp":1240396822000},"page":"15-19","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial Stimulation by DDAVP in von Willebrand\u2019s Disease and Haemophilia"],"prefix":"10.1159","author":[{"given":"I.A.","family":"Greer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.F.","family":"Belch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.D.O.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.D.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,21]]},"container-title":["Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000215264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:33:32Z","timestamp":1777739612000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000215264","archive":["Portico"],"relation":{},"ISSN":["0301-0147","1423-0038"],"issn-type":[{"value":"0301-0147","type":"print"},{"value":"1423-0038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}