{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:15:01Z","timestamp":1790061301204,"version":"4.0.1"},"reference-count":64,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and disseminated tumor cells in metastatic disease and adjuvant treatment. Because of recent technological advances, oncologists have gained a new perspective on this disease. Circulating tumor cells could be both a new tumor marker as well as a tool to gain novel insight into the natural history of this neoplastic disease.<\/jats:p>","DOI":"10.1159\/000215581","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T14:05:34Z","timestamp":1241013934000},"page":"375-386","source":"Crossref","is-referenced-by-count":23,"title":["Circulating and Disseminated Tumor Cells in the Clinical Management of Breast Cancer Patients: Unanswered Questions"],"prefix":"10.1159","volume":"76","author":[{"given":"A.","family":"Amadori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Zamarchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pastorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdl498"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4065%2F82.8.999"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02303667"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200002243420801"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.11-6-541"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.04.5948"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa050434"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186%2Fbcr942"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-05-1455"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-03-0094"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2006.01.026"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2804%2901381-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bios.2005.12.024"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2001.134"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F0032472031000141283"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa040766"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature06385"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-2821"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2005.107"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2008.18.0356"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.8.4589"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6602418"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186%2F1756-8722-1-2"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23852"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2007.13.6523"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-04-1110"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0215%2819990219%2984%3A1%3C1%3A%3AAID-IJC1%3E3.0.CO%3B2-A"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2FS0753-3322%2805%2980084-8"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1677%2FERC-06-0001"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186%2F1477-7819-4-67"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2006.079509"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.21576"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186%2Fbcr1611"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10549-005-9147-y"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0402993101"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186%2Fbcr1610"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0703071104"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-06-0169"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc865"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11864-007-0018-0"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2909838-0"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.1331931100"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.11593"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186%2Fbcr980"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-05-2553"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.20834"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc1370"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-04-0245"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200511173532016"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.20655"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.21709"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2002.08.135"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdg259"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2007.11.7762"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-2087"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1186%2Fbcr1328"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdm206"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00432-007-0248-3"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.seminoncol.2006.03.016"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-1769"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016%2F0959-8049%2895%2900317-C"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6602738"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1245%2Fs10434-007-9538-x"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:35:20Z","timestamp":1745447720000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":64,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000215581","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}