{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:46:38Z","timestamp":1745469998951,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objective:<\/i> To determine the prognostic value of myocardial perfusion scintigraphy with dipyridamole stress in patients with preexisting left bundle-branch block (LBBB) with or without chest pain. <i>Subjects and Methods:<\/i> Seventy-six patients, mean age 53 \u00b1 10 years, with preexisting LBBB underwent technetium-99m-sestamibi perfusion imaging with dipyridamole infusion protocol (0.56 mg\/kg). Stress and rest single photon emission computed tomography (SPECT) images were interpreted by consensus of 2 experienced nuclear medicine physicians and classified as low-risk scans (normal myocardial perfusion scan, small reversible\/small fixed defect) and high-risk scans (large, severe, fixed or reversible defect and dilated left ventricle cavity). The patients were followed up for 24 \u00b1 8 months and occurrences of hard cardiac events (infarction or cardiac death) were noted. <i>Results:<\/i> Of the 76 patients, 52 (68%) had low-risk scans and the remaining 24 (32%) had high-risk scans. In the low-risk group, 1 (1.9%) cardiac death and 2 (3.8%) cases of nonfatal myocardial infarction occurred, while in the high-risk group, 5 (20.8%) suffered cardiac death, and 3 (12.5%) nonfatal myocardial infarction. Overall survival rate was 98.1% in the low-risk group compared with 79.2% in the high-risk group with a significant difference of p <i>= <\/i>0.034. Negative predictive value of normal myocardial perfusion scintigraphy for the occurrence of death was 100%. No significant difference in survival rate among patients with or without chest pain (p = 0.31) was observed. <i>Conclusions:<\/i> Myocardial perfusion imaging with dipyridamole provided important prognostic information in patients with LBBB; it was useful in stratifying the patients according to cardiovascular morbidity and mortality, and would thus allow the clinician to provide early treatment especially in the high-risk category.<\/jats:p>","DOI":"10.1159\/000215730","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T12:42:59Z","timestamp":1243946579000},"page":"310-316","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of Cardiac Events in Patients Having Left Bundle-Branch Block with\/without Chest Pain Using Dipyridamole Technetium-99m-Sestamibi Myocardial Perfusion Imaging"],"prefix":"10.1159","volume":"18","author":[{"given":"Sharjeel","family":"Usmani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haider Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maseeh-Uz","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashif","family":"Niyaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2892%2990682-O"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-8703%2870%2990135-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2887%2980162-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2881%2990196-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2810%2980141-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00003072-199301000-00009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2891%2990786-K"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2895%2900329-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0402.102975"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nuclcard.2004.03.033"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1067%2Fmnc.2002.124979"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2896%2900224-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2891%2990504-E"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/215730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:36:35Z","timestamp":1745447795000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000215730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000215730","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2009]]}}}