{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:12:48Z","timestamp":1764173568101,"version":"3.40.4"},"reference-count":73,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Inhaled and intranasal glucocorticoids (GCs) are the most common and effective drugs for controlling symptoms and airway inflammation in respiratory diseases such as allergic rhinitis, chronic rhinosinusitis with\/without nasal polyps, and asthma, and the respiratory epithelium is a primary target of GC anti-inflammatory actions. GC effects are mediated through the GC receptor (GR). In humans, one single GR gene gives rise to two main GR products, namely GR\u03b1 and GR\u03b2, which are subject to translational and posttranslational modifications. GR\u03b1 is expressed in virtually all human cells and tissues, including respiratory epithelial cells, and \u2013 at least in vitro \u2013 is downregulated by GC. GR\u03b1 mediates the anti-inflammatory actions of GC by activating transcription of anti-inflammatory genes through binding of GR\u03b1 to glucocorticoid response elements (GRE) located in the promoter region of target genes, repressing transcription of proinflammatory genes through direct interaction between GR\u03b1 and proinflammatory transcription factors, such as AP-1 and NF-\u03baB (transrepression), and also by destabilizing the mRNA of proinflammatory mediators. GR\u03b2 acts as a dominant negative inhibitor of GR\u03b1-mediated transactivation and transrepression in certain in vitro studies with transfected cells. The GR\u03b2 message is expressed at low levels in numerous tissues and its protein is mainly expressed in inflammatory cells, although it has also been detected in airway epithelial cells. Increased GR\u03b2 expression has been reported in bronchial asthma and nasal polyposis, and after incubation of cells with certain proinflammatory stimuli. However, the role of GR\u03b2 in modulating GC sensitivity in vivo has been highly debated and is as yet unclear.<\/jats:p>","DOI":"10.1159\/000216187","type":"journal-article","created":{"date-parts":[[2009,7,6]],"date-time":"2009-07-06T10:41:43Z","timestamp":1246876903000},"page":"290-299","source":"Crossref","is-referenced-by-count":23,"title":["Glucocorticoid Receptor in Human Respiratory Epithelial Cells"],"prefix":"10.1159","volume":"16","author":[{"given":"Laura","family":"Pujols","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e8sar","family":"Picado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,29]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1513%2Fpats.200402-018MS"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2Fj.jaci.2007.10.041"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1111%2Fj.1398-9995.2006.01144.x"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016%2Fj.mce.2007.05.019"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1056%2FNEJMra050541"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016%2Fj.jaci.2006.01.032"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016%2Fj.tcb.2006.04.005"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016%2Fj.jsbmb.2006.09.009"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1007%2Fs11882-007-0005-3"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2Fj.mce.2007.07.003"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1007%2Fs11154-007-9059-8"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2Fj.mce.2007.04.013"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1016%2Fj.bcp.2006.07.005"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1074%2Fjbc.271.16.9550"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1128%2FMCB.01439-06"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016%2Fj.molcel.2005.03.025"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1128%2FMCB.00253-07"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1084%2Fjem.20050466"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1016%2Fj.pharmthera.2007.06.009"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1165%2Frcmb.2006-0073OC"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1111%2Fj.1398-9995.2004.00635.x"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1677%2Fjme.1.01680"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1096%2Ffj.01-0245com"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1182%2Fblood-2006-11-056853"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1016%2Fj.jaci.2006.08.027"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1164%2Frccm.200408-1041OC"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1128%2FMCB.00679-06"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1074%2Fjbc.M701325200"},{"doi-asserted-by":"publisher","key":"ref29","DOI":"10.1165%2Frcmb.2005-0176OC"},{"doi-asserted-by":"publisher","key":"ref30","DOI":"10.1210%2Fen.2006-0981"},{"doi-asserted-by":"publisher","key":"ref31","DOI":"10.1016%2Fj.steroids.2005.09.014"},{"doi-asserted-by":"publisher","key":"ref32","DOI":"10.1074%2Fjbc.272.42.26659"},{"doi-asserted-by":"publisher","key":"ref33","DOI":"10.1210%2Fme.11.8.1156"},{"doi-asserted-by":"publisher","key":"ref34","DOI":"10.1016%2FS0303-7207%2899%2900156-2"},{"doi-asserted-by":"publisher","key":"ref35","DOI":"10.1074%2Fjbc.274.39.27857"},{"doi-asserted-by":"publisher","key":"ref36","DOI":"10.1172%2FJCI117943"},{"doi-asserted-by":"publisher","key":"ref37","DOI":"10.1007%2Fs00109-001-0302-6"},{"doi-asserted-by":"publisher","key":"ref38","DOI":"10.1016%2FS0303-7207%2899%2900072-6"},{"doi-asserted-by":"publisher","key":"ref39","DOI":"10.1084%2Fjem.193.5.585"},{"doi-asserted-by":"publisher","key":"ref40","DOI":"10.1128%2FMCB.23.12.4319-4330.2003"},{"doi-asserted-by":"publisher","key":"ref41","DOI":"10.1210%2Fme.2004-0112"},{"doi-asserted-by":"publisher","key":"ref42","DOI":"10.1164%2Frccm.200507-1046OC"},{"doi-asserted-by":"publisher","key":"ref43","DOI":"10.1016%2Fj.jaci.2007.09.010"},{"doi-asserted-by":"publisher","key":"ref44","DOI":"10.1183%2F09031936.96.09102036"},{"doi-asserted-by":"publisher","key":"ref45","DOI":"10.1016%2FS0006-2952%2899%2900008-8"},{"doi-asserted-by":"publisher","key":"ref46","DOI":"10.1136%2Fthx.2003.013268"},{"doi-asserted-by":"publisher","key":"ref47","DOI":"10.1111%2Fj.1398-9995.2008.01745.x"},{"doi-asserted-by":"publisher","key":"ref48","DOI":"10.1016%2FS0091-6749%2896%2970311-1"},{"doi-asserted-by":"publisher","key":"ref49","DOI":"10.2500%2F105065801781329446"},{"doi-asserted-by":"publisher","key":"ref50","DOI":"10.1172%2FJCI116963"},{"doi-asserted-by":"publisher","key":"ref51","DOI":"10.1067%2Fmai.2002.122465"},{"doi-asserted-by":"publisher","key":"ref52","DOI":"10.1196%2Fannals.1321.007"},{"doi-asserted-by":"publisher","key":"ref53","DOI":"10.1210%2Fme.2007-0101"},{"doi-asserted-by":"publisher","key":"ref54","DOI":"10.1210%2Fme.2007-0219"},{"doi-asserted-by":"publisher","key":"ref55","DOI":"10.1124%2Fmol.105.019679"},{"doi-asserted-by":"publisher","key":"ref56","DOI":"10.1165%2Frcmb.2007-0226OC"},{"doi-asserted-by":"publisher","key":"ref57","DOI":"10.1006%2Fcimm.2001.1869"},{"doi-asserted-by":"publisher","key":"ref58","DOI":"10.1080%2F09629359890965"},{"doi-asserted-by":"publisher","key":"ref59","DOI":"10.1136%2Fthx.2007.090027"},{"doi-asserted-by":"publisher","key":"ref60","DOI":"10.1084%2Fjem.20060336"},{"doi-asserted-by":"publisher","key":"ref61","DOI":"10.1165%2Frcmb.2007-0014OC"},{"doi-asserted-by":"publisher","key":"ref62","DOI":"10.1053%2Frmed.2002.1406"},{"doi-asserted-by":"publisher","key":"ref63","DOI":"10.1164%2Frccm.200308-1143OC"},{"doi-asserted-by":"publisher","key":"ref64","DOI":"10.1189%2Fjlb.0805466"},{"doi-asserted-by":"publisher","key":"ref65","DOI":"10.1210%2Fen.138.11.5028"},{"doi-asserted-by":"publisher","key":"ref66","DOI":"10.1067%2Fmai.2000.106486"},{"doi-asserted-by":"publisher","key":"ref67","DOI":"10.1067%2Fmai.2000.105807"},{"doi-asserted-by":"publisher","key":"ref68","DOI":"10.1084%2Fjem.186.9.1567"},{"doi-asserted-by":"publisher","key":"ref69","DOI":"10.1067%2Fmai.2000.109054"},{"doi-asserted-by":"publisher","key":"ref70","DOI":"10.1067%2Fmai.2001.116428"},{"doi-asserted-by":"publisher","key":"ref71","DOI":"10.1016%2Fj.jaci.2005.12.1344"},{"doi-asserted-by":"publisher","key":"ref72","DOI":"10.1073%2Fpnas.121455098"},{"doi-asserted-by":"publisher","key":"ref73","DOI":"10.1097%2F00005537-200405000-00019"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/216187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/216187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:41:01Z","timestamp":1745448061000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000216187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":73,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000216187","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"type":"print","value":"1021-7401"},{"type":"electronic","value":"1423-0216"}],"subject":[],"published":{"date-parts":[[2009]]}}}