{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:25:03Z","timestamp":1789691103591,"version":"4.0.1"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Das Burkitt-Lymphom ist ein Tumor mit besonderen epidemiologi-schen Eigenheiten. Es ist ein sehr h\u00e4ufiger Tumor im Kindesalter in tropischen Teilen Afrikas und kommt mit viel niedrigerer Inzidenz \u00fcberall auf der Welt vor. Chromosomentranslokationen, die den langen Arm von Chromosom 8 und einen der drei Immunglobulingen-loci auf Chromsom 2, 14 oder 22 betreffen, werden regelm\u00e4\u00dfig beim Burkitt-Lymphom beobachtet, unabh\u00e4ngig von der geographischen Herkunft. Das h\u00e4ufige Auftreten des Burkitt-Lymphoms in Zentral-afrika ist mit zwei Faktoren korreliert: holo- oder hyperendemischer Malaria und Pr\u00e4senz des Epstein-Barr-Virus-Genoms in den Tumorzellen. Wir stellen hier ein neues Konzept zur Pathogenese des Burkitt-Lymphoms vor: Stimulierung des B-Zellsystems durch Malaria stellt danach den ersten Schritt in der Entwicklung des Tumors dar. Durch die vermehrte Neubildung von B-Zellen soil die Wahrscheinlichkeit f\u00fcr das Auftreten der Translokation steigen. Die Chromoso-mentranslokation und Aktivierung des Proto-Onkogens c-myc erlaubt den Zellen, auf Wachstumsfaktoren zu antworten, ohne da\u00df Proliferation direkt induziert wird. Nach unserem Modell vermittelt die Infektion mit Epstein-Barr-Virus der Zelle einen zus\u00e4tzlichen Wachstums-vorteil und treibt sie weiter in Richtung maligne Zellen.<\/jats:p>","DOI":"10.1159\/000216407","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T08:49:09Z","timestamp":1240822149000},"page":"196-204","source":"Crossref","is-referenced-by-count":3,"title":["Chromosomentranslokationen und Epstein-Barr-Virus beim Burkitt-Lymphom"],"prefix":"10.1159","author":[{"given":"G.W.","family":"Bornkamm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Polack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,4,24]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/216407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000216407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:01:51Z","timestamp":1777680111000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000216407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000216407","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,24]]}}}