{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:28:26Z","timestamp":1777930106905,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>23 Patienten mit Extravasatkomplikationen nach intraven\u00f6ser Zytostatikatherapie wurden in einer offenen Pilotstudie mit Tetrachlor-decaoxid (TCDO, Oxoferin\u00ae) als lokalem Wundfeucht-Therapeutikum behandelt. TCDO hatte bei chronischen ven\u00f6sen wie arteriellen Ulcera an den Beinen eine aktive F\u00f6rderung der Wundheilung gezeigt, die auf eine Stimulierung der Phagozytose mit Gewebstr\u00fcmmerbeseitigung und Steigerung makrophagenkontrollierter Zellproliferationen zur\u00fcckgef\u00fchrt wurde. Diese pharmakodynamischen Eigenschaften haben uns veranla\u00dft, TCDO bei der oben beschriebenen Indikation anzuwenden. Obwohl in der Literatur die H\u00e4ufigkeit der Entstehung von Ulcera bei Zytostatika-Extravasaten mit 90% angegeben wird, konnte bei alien 17 Patienten, bei denen die TCDO-Behandlung im dermatitisch-phlebitischen Fr\u00fchstadium begonnen worden war, diese Sp\u00e4tkomplikation verhindert werden. Bei 5 von 6 Patienten mit torpiden Ulcera war durch die TCDO-Behandlung 2 Monate nach Therapieende eine vollst\u00e4ndige Abheilung erzielt worden. Trotz aller Zur\u00fcckhaltung, mit welcher Ergebnisse einer offenen Studie bewertet werden m\u00fcssen, ist festzuhalten, da\u00df so deutliche Resultate zu der Annahme f\u00fchren, da\u00df TCDO in der Lage ist, in die bei diesen L\u00e4sionen stark gest\u00f6rte Geweberegeneration kausal einzugreifen.<\/jats:p>","DOI":"10.1159\/000216533","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T08:49:09Z","timestamp":1240822149000},"page":"238-240","source":"Crossref","is-referenced-by-count":1,"title":["Verhinderung von Extravasatnekrosen als Komplikation nach intraven\u00f6ser Zytostatikatherapie"],"prefix":"10.1159","author":[{"given":"K.","family":"Kolaric","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zupanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.W.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ivankovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,27]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/216533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000216533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:04:04Z","timestamp":1777680244000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000216533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000216533","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,27]]}}}