{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:29:11Z","timestamp":1777930151650,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>The impact of recombinant human tumor necrosis factor-\u03b1 (rhTNF-\u03b1), given alone or in combination with local hyperthermia, on perfusion and growth of a moderately rhTNF-\u03b1-sensitive rat tumor (DS-carcinosarcoma) was investigated. DS-carcinosarcomas were implanted into the hind foot dorsum of Sprague-Dawley rats. Tumor blood flow (TBF) was measured with the krypton-85 clearance technique. Treatment with either tumor necrosis factor-\u03b1 (0.1\u20131.0 mg\/kg) or hyperthermia (43.3 and 44.3\u00b0C, 40 min) can decrease the perfusion of malignant tumors. The TBF reduction was fully established 2h after rhTNF-\u03b1 injection and lasted for at least 4 h. The application of local hyperthermia (T &gt; 42\u00b0C) 3h after rhTNF-\u03b1 administration further diminished tumor blood flow. Volume growth of the tumors was monitored during repeated treatment. rhTNF-\u03b1 (0.2 and 1.0 mg\/kg i.v.) combined with hyperthermia (43.3 and 44.3\u00b0C, 40min, starting 3 h after rhTNF-\u03b1 injection) were given every third day from the fifth to the 20th day after tumor implantation. Mono therapies retarded tumor growth in a dose-dependent manner. Combined treatment was superior to either monotherapy leading to local tumor control in 40\u201350% of the animals treated. It is concluded that local hyperthermia can enhance the efficacy of rhTNF-\u03b1 treatment by further reducing tumor perfusion.<\/jats:p>","DOI":"10.1159\/000216620","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T10:05:34Z","timestamp":1240999534000},"page":"131-135","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Tumor Necrosis Factor-\u03b1 on Tumor Blood Flow and Hyperthermic Treatment"],"prefix":"10.1159","author":[{"given":"F.","family":"Kallinowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Moehle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vaupel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,27]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/216620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000216620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:05:19Z","timestamp":1777680319000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000216620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000216620","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,27]]}}}