{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:29:50Z","timestamp":1777930190827,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onkologie"],"abstract":"<jats:p>Der mit Hodgkin- und Reed-Sternberg-Zellen assoziierte monoklonale Antik\u00f6rper HRS-1 wurde mit radioaktivem Jod markiert und sechs Patienten mit Hodgkin-Lymphom injiziert. Vier von f\u00fcnf Patienten, die 131Jod-markierten HRS-1 erhalten hatten, hatten ein positives Immunszintigramm. Der sechste Patient erhielt 123Jod-markierten HRS-1 zur Durchf\u00fchrung eines SPECT-Tomoszintigramms. Bei diesem Patienten lie\u00df sich ein Knochenbefall nachweisen. Diese ersten Ergebnisse zeigen, da\u00df eine Immunszintigraphie mit Jod-markiertem HRS-1 wichtige diagnostische Informationen bei Hodgkin-Lymphomen erbringen kann. Der tats\u00e4chliche klinische Stellenwert der Immunszintigraphie bei Hodgkin-Lymphomen mu\u00df in einer Studie mit gr\u00f6\u00dferen Patientenzahlen bestimmt werden. Technische Modifikationen wie z.B. die Verwendung von F(ab) oder F(ab)&lt;sub&gt;2&lt;\/sub&gt;-Fragmenten sollten zu einer weiteren Verbesserung dieses neuartigen diagnostischen Verfahrens f\u00fchren.<\/jats:p>","DOI":"10.1159\/000216681","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T10:05:34Z","timestamp":1240999534000},"page":"30-33","source":"Crossref","is-referenced-by-count":3,"title":["In-vivo-Imaging von Hodgkin-Lymphomen mit monoklonalen Antik\u00f6rpern"],"prefix":"10.1159","author":[{"given":"M.","family":"Pfreundschuh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Carde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Manil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-D.","family":"Lumbroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Caillou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Boudet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ricard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Parmentier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-C.","family":"Saccavini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,27]]},"container-title":["Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/216681","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000216681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:06:18Z","timestamp":1777680378000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000216681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000216681","archive":["Portico"],"relation":{},"ISSN":["0378-584X","1423-0240"],"issn-type":[{"value":"0378-584X","type":"print"},{"value":"1423-0240","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,27]]}}}