{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:55:57Z","timestamp":1767898557191,"version":"3.49.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> A history of pre-eclampsia has been shown to be associated with an increased risk of subsequent coronary artery disease. The intima-media thickness of carotid arteries and the detection of plaques are useful measures as regards preclinical atherosclerosis. The aim of this study was to examine whether women with a history of pre-eclampsia more often show signs of atherosclerosis compared with 2 control groups. <i>Methods:<\/i> We used data from a large Finnish cross-sectional health examination survey. We had women with previous pre-eclampsia (n = 35) or pregnancy-induced hypertension (n = 61) and 2 control groups. Laboratory tests and physical examination were performed. Information on reproductive and medical history was obtained at the home interview. Carotid atherosclerosis was assessed by ultrasonography. <i>Results:<\/i> The women with previous pre-eclampsia had significantly (p = 0.008) more atherosclerotic plaques than the healthy parous controls. The intima-media thickness in the women with previous pre-eclampsia also tended to be higher than in the other groups, although the differences did not reach statistical significance. In logistic regression analysis, advanced age (OR: 1.08; 95% CI: 1.04\u20131.13; p < 0.001) and pre-eclampsia (OR: 3.63; 95% CI: 1.50\u20138.79; p = 0.004) were independent risk factors as regards plaque, and in linear regression analysis advanced age (estimate: 0.012; 95% CI: 0.010\u20130.014; p < 0.001), HDL cholesterol (estimate: \u20130.049; 95% CI: \u20130.088 to \u20130.010; p = 0.013), systolic blood pressure, BMI (estimate: 0.005; 95% CI: 0.000\u20130.009; p = 0.043) and high-sensitivity C-reactive protein (estimate: \u20130.003; 95% CI: \u20130.007 to \u20130.000; p = 0.048) were independent risk factors with respect to intima-media thickness. <i>Conclusions:<\/i> Our data suggest that pre-eclampsia is an independent risk factor as regards developing plaque later in life.<\/jats:p>","DOI":"10.1159\/000216834","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T14:05:34Z","timestamp":1241013934000},"page":"599-607","source":"Crossref","is-referenced-by-count":43,"title":["Pre-Eclampsia Is a Risk Factor of Carotid Artery Atherosclerosis"],"prefix":"10.1159","volume":"27","author":[{"given":"L.","family":"Haukkamaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Moilanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kattainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Luoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.A.","family":"Kes\u00e4niemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kaaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903577-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2898%2900208-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.12.1607"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000074428.11168.EE"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.grf.0000160316.67359.3d"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.obstetgynecol.2003.08.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ede.0000152912.02042.cd"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.325.7356.157"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.326.7394.845"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2004.01.038"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2003.11.065"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2905112-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000103114"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000106979"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1747-4949.2006.00068.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F00016340701464374"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2FHJH.0b013e3280d94336"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F01.hjh.0000217859.27864.19"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001250051565"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000166196.31227.91"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000107381"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0026-0495%2899%2990225-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000143849.67254.ca"}],"container-title":["Cerebrovascular 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