{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T02:42:00Z","timestamp":1785638520495,"version":"3.56.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Although the anticaries effect of fluoride (F) dentifrices is clearly established, the relative importance of F taken up by dental plaque not removed by brushing and of F products (CaF&lt;sub&gt;2&lt;\/sub&gt;-like) formed on totally cleaned enamel for the subsequent inhibition of demineralization is not known. Both effects were evaluated using conventional (1,100 \u03bcg F\/g) and low-F concentration (500 \u03bcg F\/g) dentifrices in a randomized, crossover, double-blind in situ study. Enamel blocks not treated or pretreated with the dentifrices to form CaF&lt;sub&gt;2&lt;\/sub&gt;-like deposits were mounted in palatal appliances in contact with a &lt;i&gt;Streptococcus mutans&lt;\/i&gt; test plaque. Volunteers brushed with non-F (negative control), low-F or conventional dentifrices and inserted the appliance in the mouth. F concentration in the fluid and solid phases of the test plaque was determined after 30 min, and a rinse with 20% sucrose solution was performed. After additional 45 min, plaque was collected and the loss of surface hardness at different test-plaque depths was measured. CaF&lt;sub&gt;2&lt;\/sub&gt;-like deposition on enamel and F taken up by plaque due to the use of F dentifrices were able to significantly increase F concentration in the fluid phase of the test plaque, but only the latter significantly reduced the loss of hardness because of the 20\u201330 times higher F concentration. Also, significant differences between the low-F and conventional dentifrices were observed for F on enamel, in plaque and on the subsequent loss of hardness. The results suggest that uptake of F by dental plaque not removed by brushing may be the main cause of the anticaries effect of F dentifrices.<\/jats:p>","DOI":"10.1159\/000217860","type":"journal-article","created":{"date-parts":[[2009,5,18]],"date-time":"2009-05-18T11:20:34Z","timestamp":1242645634000},"page":"278-285","source":"Crossref","is-referenced-by-count":53,"title":["Mechanism of Fluoride Dentifrice Effect on Enamel Demineralization"],"prefix":"10.1159","volume":"43","author":[{"given":"L.M.A.","family":"Tenuta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Zamataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Del Bel Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.M.","family":"Tabchoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0722.1996.tb00104.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000260797"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000261524"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9969%2875%2990023-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000151663"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F00016358809004784"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000070444"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000084807"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177%2F154407370802000104"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1590%2FS0103-64402004000300001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000261354"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000261612"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000111749"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177%2F154405910408300114"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000049110"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000261218"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0722.1997.tb00231.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177%2F154405910608500911"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177%2F154405910808701105"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177%2F00220345920710030501"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/217860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/217860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:20:34Z","timestamp":1745446834000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000217860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000217860","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}