{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:05:27Z","timestamp":1758279927799,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; To evaluate injury to the myenteric interstitial cells of Cajal (ICC-MY) and assess the role of ICC-MY in gastrointestinal motility in rat models of abdominal sepsis and intra-abdominal hypertension (IAH). &lt;i&gt;Materials and Methods:&lt;\/i&gt; Sprague-Dawley rats were divided into 4 groups; group 1: sham group; group 2: sepsis induced by cecal puncture and ligation; group 3: IAH created by placing a catheter into the abdominal cavity; group 4: sepsis and IAH induced simultaneously. Small intestinal segments were resected 24 h after surgery. Ileum sections stained with HE were assessed pathologically. The spontaneous mechanical activity was evaluated using the organ bath technique. The alterations in ICC-MY networks by immunohistochemical staining for c-Kit and the ultrastructural changes in ICC-MY by transmission electron microscopy were evaluated. &lt;i&gt;Results:&lt;\/i&gt; There were significant differences in the frequency and amplitude of the bowel segment contractions between groups 1, 2, 3 and 4. These changes were associated with lesions of ICC-MY networks and ultrastructure. &lt;i&gt;Conclusions:&lt;\/i&gt; Abdominal sepsis and IAH resulted in damage to ICC-MY networks, leading to disordered intestinal rhythmicity. The combination of sepsis and IAH causes far more serious injury than either sepsis or IAH alone.<\/jats:p>","DOI":"10.1159\/000218102","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T13:26:39Z","timestamp":1242221199000},"page":"47-52","source":"Crossref","is-referenced-by-count":12,"title":["Interstitial Cells of Cajal in Abdominal Sepsis and Hypertension-Induced Ileus in Rats"],"prefix":"10.1159","volume":"43","author":[{"given":"Zheng","family":"Lou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie Shou","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.1996.v111.pm8690216"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0074-7696%2803%2929004-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F373347a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1679%2Faohc.65.1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00595-006-3196-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2006.04.022"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-7793.2001.0555c.xd"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpgi.00359.2003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpgi.00077.2004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2896%2970005-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00428-006-0258-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2004.09.053"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/218102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/218102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:21:07Z","timestamp":1745446867000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000218102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000218102","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2009]]}}}