{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:12:42Z","timestamp":1759601562589,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Recent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer\u2019s disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in &lt;i&gt;NCAPD2 &lt;\/i&gt;(rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese.<\/jats:p>","DOI":"10.1159\/000218740","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T17:58:18Z","timestamp":1242410298000},"page":"508-512","source":"Crossref","is-referenced-by-count":12,"title":["A Study on the Association of the Chromosome 12p13 Locus with Sporadic Late-Onset Alzheimer\u2019s Disease in Chinese"],"prefix":"10.1159","volume":"27","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leung Wing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Yiu","family":"Yik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Qiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.278.15.1237"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.281.6.513"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.280.7.619"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.280.7.614"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1086%2F302828"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0403535101"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10048-008-0122-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000082661"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2007.03094.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2898%2900470-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000095723"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fbioinformatics%2Fbth457"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2105-8-36"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0404730102"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.30525"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1013266411263"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gene.2007.04.020"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1086%2F324773"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2F1243"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddg007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000223438.90113.4e"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/218740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/218740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:28:06Z","timestamp":1745447286000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000218740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000218740","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5120713","asserted-by":"subject"}]},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2009]]}}}