{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:26:34Z","timestamp":1760081194653,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>A pronounced linear eruption with ulcerations and calcium extrusion present in a boy with a mild generalized rash clinically consistent with juvenile dermatomyositis or overlap syndrome is reported. Loss of heterozygosity (LOH) is a postzygotic mechanism by which a heterozygous somatic cell may become homozygous or hemizygous at a given gene locus. Such a mechanism can be suspected when a pronounced segmental manifestation of an acquired skin condition with a polygenic background is found to be superimposed on more or less symmetrically distributed nonsegmental lesions of the same disorder. Alternatively, such a segmental manifestation may reflect heterozygosity for a postzygotic mutation involving an additional gene locus. The severe linear lesions in our patient showed a Blaschko-linear arrangement and were superimposed on mild nonsegmental lesions of either amyopathic dermatomyositis or overlap syndrome. Either LOH or a postzygotic mutation at an additional gene locus may explain the pronounced linear involvement.<\/jats:p>","DOI":"10.1159\/000219246","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T13:27:04Z","timestamp":1242221224000},"page":"155-157","source":"Crossref","is-referenced-by-count":13,"title":["Pronounced Linear Calcinosis in a Boy with Mild Dermatomyositis"],"prefix":"10.1159","volume":"219","author":[{"given":"Mar\u00eda","family":"del Carmen Boente","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Nadra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Asial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Happle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.129.11.1460"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2891%2970245-W"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.104.2.166"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1994.tb08473.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2961515-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000246418"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1996.tb01159.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1988.tb02604.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.1996.tb01453.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.130.9.1206"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.130.9.1207"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2893%2970126-E"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1470.1990.tb01031.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1989.tb01383.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1996.tb01160.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.28.5.337"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970042-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2007.06.039"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1976.tb00835.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.117.2.63a"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1996.tb16258.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/219246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/219246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:33:03Z","timestamp":1745447583000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000219246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000219246","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2009]]}}}