{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:43:09Z","timestamp":1777765389545,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T00:00:00Z","timestamp":1242777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T00:00:00Z","timestamp":1242777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"abstract":"<jats:p>The authors administered ethambutol (EMB) in doses of 25 mg\/kg body weight daily for 2 months and 15 mg\/kg body weight in another period to 55 patients of whom they have assessed only 50. These are patients who could be followed up for at least 3 months. 46 of them had pulmonary tuberculosis, 2 basilar meningitis, 1 tuberculosis of bones and joints and 1 specific adnexitis. Patients were in question whose common feature lay in difficult curability owing to the resistance of tubercle bacilli (48%), hepatic lesion (63%), intolerance of drugs (50%) and serious superposed diseases (46%). EMB was combined with one or two efficient drugs that could be applied. Therapeutic results were assessed in all patients whose therapy lasted at least 4 months (4\u201321 months, average 8 months). Patients who excreted tubercle bacilli were rendered negative. Negativity was obtained sooner if the drug combination contained RAMP. Radiologically, once aggravation of the cavernous process ensued. EMB was discontinued once after 14 days and once after 21 months of treatment owing to increasing values of the liver function tests. The first woman patient had had epidemic hepatitis and showed an allergic reaction to SM and VM, the other patient recovered from a severe hepatic lesion with icterus after MZA. The treatment was twice interrupted for fear of a possible damage to sight after degenerative alterations had been ascertained on the eyeground after 2 and 4 months of therapy but they did not fall within the aspect of retrobuloar Walsh\u2019s neuritis. Tolerance of EMB was very good, no subjective troubles were ascertained.<\/jats:p>","DOI":"10.1159\/000221245","type":"journal-article","created":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T11:08:22Z","timestamp":1243249702000},"page":"41-62","source":"Crossref","is-referenced-by-count":0,"title":["Ethambutol in Therapy of Complicated Tuberculosis"],"prefix":"10.1159","author":[{"given":"J.","family":"Tou\u0161ek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pape\u017eov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,20]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/221245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000221245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:22:40Z","timestamp":1777476160000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000221245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000221245","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,20]]}}}