{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:43:56Z","timestamp":1777765436236,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T00:00:00Z","timestamp":1243209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T00:00:00Z","timestamp":1243209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"abstract":"<jats:p>The effect of intraperitoneally applied 1.3-bis(piperidinomethyl)-5-ethyl-5-phenyl-barbituric acid on immune response in mice has been investigated. A marked depression of antihuman erythrocyte agglutinin titers was found following primary and secondary immunization; in the latter it mainly concerned 2-mercaptoethanol resistant antibodies. The immunological memory was influenced, too. The effects on humoral antibody reaction were dependent on dosage and timing. Chronic substance administration produced a lower progression of autoimmune nephropathy in (NMRI\u00d7NZB)F&lt;sub&gt;1&lt;\/sub&gt; hybrid mice as evaluated by immunofluorescence photometry. However, the depression of circulating hemagglutinins did not coincide with a concomitant inhibition of cell-mediated immunity as examined by means of contact sensitivity and skin allografting in mice and phytohemagglutinin-stimulated human lymphocytes in vitro.<\/jats:p>","DOI":"10.1159\/000221469","type":"journal-article","created":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T11:08:22Z","timestamp":1243249702000},"page":"305-313","source":"Crossref","is-referenced-by-count":6,"title":["Immunosuppressive Effects of Barbituric Acid Derivatives"],"prefix":"10.1159","author":[{"given":"J.","family":"G\u00fcttner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Heinecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"K\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,25]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/221469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000221469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:23:43Z","timestamp":1777476223000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000221469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000221469","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,25]]}}}