{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:43:57Z","timestamp":1777765437496,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T00:00:00Z","timestamp":1243209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T00:00:00Z","timestamp":1243209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"abstract":"<jats:p>In 1972, 8 registered typhoid carriers and 1 carrier of Salmonella bareilly were treated with amoxycillin (Amoxil) and with Amoxil + probenecid in our department. All Salmonella strains were found to be sensitive to Amoxil. After continuous oral administration of Amoxil (3 g\/day) and after giving Amoxil + probenecid (2 g Amoxil + 1 g probenecid daily), the mean value of Amoxil concentration in the bile was 19 and 46 \u03bcg\/ml, respectively. On the basis of the observation period (7 months to date), 6 typhoid carriers and 1 carrier of Salmonella bareilly can be considered recovered. In 2 cases who underwent a cholecystectomy prior to the Amoxil treatment (\u2018short term treatment\u2019 lasting 18 days), a bacteriological relapse was observed on the 12th and 18th day after treatment. Side effects or allergic manifestations were not observed. On the evidence of our observations, the \u2018long-term treatment\u2019 (lasting 35 days) of typhoid carriers with Amoxil (3 g\/day) or with Amoxil + probenecid (2 g Amoxil + 1 g probenecid\/day) is undoubtedly advisable.<\/jats:p>","DOI":"10.1159\/000221788","type":"journal-article","created":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T11:08:22Z","timestamp":1243249702000},"page":"29-38","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of Typhoid Carriers with Amoxycillin and in Combination with Probenecid"],"prefix":"10.1159","author":[{"given":"D.","family":"M\u00fcnnich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"B\u00e9k\u00e9si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bardovics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,25]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/221788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000221788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:23:45Z","timestamp":1777476225000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000221788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000221788","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,25]]}}}