{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:55:28Z","timestamp":1771235728110,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Cephalosporins can induce severe or life-threatening IgE-mediated reactions in some individuals. In this study, we wish to describe a group of non-penicillin-allergic patients who were evaluated for immediate allergic reactions to cephalosporins. &lt;i&gt;Methods:&lt;\/i&gt; The patients were assessed by skin tests with the culprit cephalosporin as well as with other cephalosporins and penicillins. If indicated, oral challenge testing was performed. &lt;i&gt;Results:&lt;\/i&gt; Six patients were assessed. A total of 42 skin tests and 20 oral challenges were performed. In 4 patients, skin tests included the causative drug; in 2 patients, the diagnosis of a cephalosporin allergy was made by skin test; in 4 patients, the diagnosis of a cephalosporin hypersensitivity was made by oral challenge. In 96.9% of the oral challenges, which were done using medications with no structural side chain similarities to the culprit drug, no adverse reaction occurred. &lt;i&gt;Conclusion:&lt;\/i&gt; A positive skin test to cephalosporin implies the presence of drug-specific IgE antibodies. Cephalosporins without side chain similarities are suggested to patients with cephalosporin reactions and no \u03b2-lactam reactivity.<\/jats:p>","DOI":"10.1159\/000222672","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T19:04:37Z","timestamp":1244228677000},"page":"205-209","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of Immediate Allergic Reactions to Cephalosporins in Non-Penicillin-Allergic Patients"],"prefix":"10.1159","volume":"150","author":[{"given":"Raz","family":"Somech","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasson","family":"Lavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMcp043986"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-198700342-00009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.10.032"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4065%2F80.3.405"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2961016-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1276"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.iac.2004.03.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.11.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.all.0000173788.73401.69"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2803%2901783-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2174%2F138161208786369731"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2003.00279.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2970138-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-3038.2005.00280.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2970101-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2889%2990122-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.111147"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/222672","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/222672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:59:57Z","timestamp":1745449197000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000222672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000222672","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}