{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:51:46Z","timestamp":1776444706668,"version":"3.51.2"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Eosinophilic pneumonia is characterized by the prominent accumulation of eosinophils and lymphocytes in the lung parenchyma. Liver-expressed chemokine (LEC)\/CC chemokine ligand 16 (CCL16) is a novel functional ligand for H4 which is expressed on eosinophils and also an affinity ligand for CCR1, CCR2, CCR5 and CCR8 which are expressed on T lymphocytes and monocytes. The purpose of this study is to clarify the role of LEC\/CCL16 in eosinophilic pneumonia. &lt;i&gt;Methods:&lt;\/i&gt; The LEC\/CCL16 level was measuredusing an enzyme-linked immunosorbent assay in the bronchoalveolar lavage fluid (BALF) of 33 patients with eosinophilic pneumonia, 26 patients with sarcoidosis and 10 healthy volunteers. The cell sources of LEC\/CCL16 in BALF were evaluated by immunocytochemistry. &lt;i&gt;Results:&lt;\/i&gt; The LEC\/CCL16 levels in BALF from patients with eosinophilic pneumonia were significantly higher than those from patients with sarcoidosis and healthy volunteers. The BALF LEC\/CCL16 levels correlated with the numbers of BALF eosinophils and lymphocytes, respectively. The BALF LEC\/CCL16 levels were significantly decreased after remission in eosinophilic pneumonia. In immunocytochemistry, the LEC\/CCL16 expression was clearly observed in CD1a-positive dendritic cells as well as in CD68-positive macrophages harvested from patients with eosinophilic pneumonia, but not from the controls. &lt;i&gt;Conclusions:&lt;\/i&gt; These results suggest that LEC\/CCL16 produced by dendritic cells as well as by alveolar macrophages contributes to the accumulation of eosinophils and lymphocytes into the inflamed lungs of patients with eosinophilic pneumonia.<\/jats:p>","DOI":"10.1159\/000222681","type":"journal-article","created":{"date-parts":[[2009,6,8]],"date-time":"2009-06-08T14:51:42Z","timestamp":1244472702000},"page":"282-290","source":"Crossref","is-referenced-by-count":6,"title":["Elevated Concentrations of Liver-Expressed Chemokine\/CC Chemokine Ligand 16 in Bronchoalveolar Lavage Fluid from Patients with Eosinophilic Pneumonia"],"prefix":"10.1159","volume":"150","author":[{"given":"Shin-ichi","family":"Nureki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishi","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Usagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Kumamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198908313210903"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM196904102801501"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-939522"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.109827"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.01.17509620"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000086335"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2005.03.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fintimm%2F13.8.1021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1998.8762"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-939517"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2007.09.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2F1477-7827-5-18"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.2003.01230.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2003.00149.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2004.00492.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199909%2929%3A09%3C2684%3A%3AAID-IMMU2684%3E3.0.CO%3B2-Y"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/222681","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/222681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:00:01Z","timestamp":1745449201000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000222681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000222681","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}