{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:06:16Z","timestamp":1768518376538,"version":"3.49.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Introduction:<\/i> Cerebral hypoperfusion caused by large vessel atherosclerosis has been suggested to be associated with the pathogenesis of sporadic Alzheimer\u2019s disease (AD). Atherosclerosis and AD share risk factors such as age, diabetes, hypercholesterolemia, hypertension and apolipoprotein E \u03b54 (APOE \u03b54) allele. We studied the association between atherosclerosis of the circle of Willis (CW) and AD neuropathology in a large autopsy sample. <i>Methods:<\/i> The present study comprised a consecutive autopsy series (n = 466) representing noninstitutionalized general population aged 50 years and over (mean 70.8, SD 11.5 years). The atherosclerosis of CW was scored semiquantitatively and the amyloid plaque (AP) load in the frontal cortex and the number of neurofibrillary tangles (NFT) in the hippocampus were measured. <i>Results:<\/i> In a linear regression model, AP percentage area was associated with age (p < 0.0001) and APOE \u03b54 allele (p < 0.0001), but not with CW score (p = 0.70) or gender (p = 0.11). Similarly, the NFT count was predicted only by age (p > 0.0001), and not by CW score (p = 0.36), gender (p = 0.41) or APOE \u03b54 allele (p = 0.072). <i>Conclusion:<\/i> Our results suggest that cerebral large vessel atherosclerosis is not in direct association with APs or NFTs \u2013 hallmarks of AD neuropathology.<\/jats:p>","DOI":"10.1159\/000222779","type":"journal-article","created":{"date-parts":[[2009,6,12]],"date-time":"2009-06-12T14:29:57Z","timestamp":1244816997000},"page":"93-98","source":"Crossref","is-referenced-by-count":32,"title":["Large Vessel Cerebral Atherosclerosis Is Not in Direct Association with Neuropathological Lesions of Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"62","author":[{"given":"Teemu M.","family":"Luoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu","family":"Haikonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Haapasalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirkka","family":"Goebeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Erkinjuntti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka J.","family":"Karhunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00041444-200512000-00009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1196%2Fannals.1297.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2806%2970537-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1179%2F016164104225017668"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-006-0136-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000095973.42032.44"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000143317.70478.b3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.wad.0000201855.39246.2d"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20516"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2804%2900683-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000054050.51530.76"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000102660.99744.85"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000150886.50187.30"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20493"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000248777.44128.93"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2000.tb06374.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2895%2900021-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00007425"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/222779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/222779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:01:23Z","timestamp":1745449283000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000222779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000222779","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}