{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:19Z","timestamp":1789609099610,"version":"build-2803163510"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Adult-onset Henoch-Sch\u00f6nlein purpura (HSP) tends to become chronic-relapsing, yet rarely leads to organ impairment, e.g. due to chronic glomerulonephritis. Bed rest, compression and nonsteroidal anti-inflammatory drugs are usually sufficient to control the active phases. We report 2 cases of adult HSP with an unusually severe evolution. One patient required intensive-care treatment for hypovolemic shock caused by hemorrhagic pancolitis; the other had progressive and extremely extensive vasculitic leg ulcers. Both were refractory to common immunosuppression with systemic corticosteroids (oral and pulse) and additive steroid-sparing immunosuppressive drugs. Only after the introduction of plasmapheresis did both patients show a dramatic improvement in the disease, with rapid and almost complete healing. Plasmapheresis is a rarely used therapeutic tool in the treatment of severe HSP, but the growing literature on its highly beneficial effect underlines its potential usefulness.<\/jats:p>","DOI":"10.1159\/000223237","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T14:30:26Z","timestamp":1243607426000},"page":"167-170","source":"Crossref","is-referenced-by-count":25,"title":["Life-Threatening or Organ-Impairing Henoch-Sch\u00f6nlein Purpura: Plasmapheresis May Save Lives and Limit Organ Damage"],"prefix":"10.1159","volume":"219","author":[{"given":"Davide","family":"Donghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Schanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Sahrbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Recher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph M.","family":"Tr\u00fceb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3949%2Fccjm.69.Suppl_2.SII87"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.10.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000181970"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2000.16221"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2003.04539.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780390425"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-004-1514-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2FMOP.0b013e3282f4308b"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11926-004-0068-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1537-2995.2003.00397.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080%2F08916930600972040"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670000477"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10067-005-0113-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2008.02211.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250500509180"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-004-1673-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-007-0498-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2899%2970178-2"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/223237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/223237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:06:43Z","timestamp":1745449603000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000223237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000223237","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}