{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:58:49Z","timestamp":1777870729349,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T00:00:00Z","timestamp":1243468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T00:00:00Z","timestamp":1243468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infusionsther Transfusionsmed"],"abstract":"<jats:p>Objective: Fibronectin (Fn) plays an important part in unspecific defense mechanisms because of its ability to mediate the binding of foreign-body particles, bacteria, collagen, and other macromolecules to phagocytising cells of the reticulo-endothe-lial system (RES). The aim of the present study was to examine the effect of a 10-day hemodilution therapy on Fn concentration in humans. Design: The patients were randomized and treated with either 10% hydroxyethyl starch (HES) 200\/0,62 or 6% HES 200\/0,62. Setting: Neurology department of an university clinic. Patients: We examined 12 patients with cerebrovascular perfusion disturbances. Interventions: The Fn concentration was determined using simple radial immunodif-fusion. Results: The Fn concentration dropped significantly in all 12 patients (p &lt; 0.01) in a dose-dependent manner beyond the dilution effect. 10% HES 200\/0,62 caused a Fn decrease from 26.6 \u00b1 9.2 to 10.0 \u00b1 2.2 mg\/dl (-62.2%), 6% HES reduced Fn from 25.5 \u00b1 9.9 to 15.0 \u00b1 3.2 mg\/dl (-41.1%). In one patient there was a continuous decrease of Fn from 41.0 down to only 6.4 mg\/dl. Conclusion: According to the results of animal experiments, the decrease of Fn seems to indicate depression of the RES. Besides its defense function, Fn probably plays a role in embryogenesis, wound healing, and blood clotting. Therefore, we assume that the drug-induced reduction of Fn possibly has clinical relevance.<\/jats:p>","DOI":"10.1159\/000223261","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T10:32:52Z","timestamp":1243593172000},"page":"71-75","source":"Crossref","is-referenced-by-count":0,"title":["Decrease of Fibronectin Following Repeated Infusion of Highly Substituted Hydroxyethyl Starch"],"prefix":"10.1159","author":[{"given":"J.","family":"Treib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Haass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pindur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Grauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Schimrigk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,5,28]]},"container-title":["Infusionstherapie und Transfusionsmedizin \/ Infusion Therapy and Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/223261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000223261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:36:18Z","timestamp":1777566978000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000223261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000223261","archive":["Portico"],"relation":{},"ISSN":["1019-8466","1423-0089"],"issn-type":[{"value":"1019-8466","type":"print"},{"value":"1423-0089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,28]]}}}