{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:48:09Z","timestamp":1745470089767,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Thyroid disturbances are common in kidney graft recipients and they may influence graft function. CXC chemokine ligand 10 plays a role in both autoimmune thyroiditis and graft rejection. Thyroid antibody (Ab) positivity has been regarded as a marker of imbalance of the immune system. &lt;i&gt;Aim:&lt;\/i&gt; To relate pretransplant positivity for antithyroperoxidase (TPO) Ab and antithyroglobulin (Tg) Ab with kidney graft outcome. &lt;i&gt;Methods:&lt;\/i&gt; Pretransplant thyroid antibodies were measured in 211 kidney graft recipients. &lt;i&gt;Results:&lt;\/i&gt; The 5-year death-censored graft survival rate was 91.5%. Pretransplant circulating Tg Ab and TPO Ab were detected in 12 (5.7%) and 13 (6.2%) patients, respectively. Lifetime analysis showed similar 5-year graft survival rates in patients negative or positive for Tg Ab and TPO Ab (91.5 vs. 91.7% for Tg Ab and 91.9 vs. 84.6% for TPO Ab). However, patients with pretransplant positivity for TPO Ab showed a significantly lower 5-year graft survival when early graft loss (12 months after transplant) was excluded (84.6 and 96.8% for TPO Ab+ and TPO Ab\u2013 patients, respectively; p &lt; 0.05). Occurrence of acute rejection and chronic allograft nephropathy was unrelated to thyroid Ab positivity. Serum CXC chemokine ligand10 levels were similar independent of Tg Ab and TPO Ab positivity. &lt;i&gt;Conclusion:&lt;\/i&gt; Pretransplant positivity for TPO Ab may affect long-term graft survival in kidney graft recipients independent of occurrence of acute rejections and chronic allograft nephropathy.<\/jats:p>","DOI":"10.1159\/000223416","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T19:04:37Z","timestamp":1244228677000},"page":"324-330","source":"Crossref","is-referenced-by-count":0,"title":["Pretransplant Positivity for Circulating Thyroid Antibodies and Graft Survival in Patients Undergoing Kidney Transplant"],"prefix":"10.1159","volume":"71","author":[{"given":"Mario","family":"Rotondi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Leporati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lodigiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Stefano","family":"Netti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Precerutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Magri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pradella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Salvadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Serio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Romagnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Chiovato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.17.1.45"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0041-1345%2803%2900768-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2006.10.137"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.1.151"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00169.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2800%2980165-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2F35065016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.2006-0044"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.192.10.1515"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.193.8.975"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-0977"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2004.00525.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000160759.85080.2E"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0834"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1500751"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.2.489"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMe030096"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2004.00332.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2006.02531.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/223416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/223416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:08:42Z","timestamp":1745449722000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000223416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000223416","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2009]]}}}