{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:39:49Z","timestamp":1773275989958,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Chronic autoimmune thyroiditis (CAT) displays a strong female predominance with female-to-male (F:M) ratios of 4\u201320:1 in adults and 2\u20139:1 in children and adolescents. Both genetic and hormonal factors are involved in this phenomenon. The relation between puberty and F:M ratio in CAT has never been evaluated. <i>Methods:<\/i> The F:M ratio of 133 children with CAT (group A, age at diagnosis 2.4\u201317.7 years) was compared with that of 113 adult CAT patients (group B, age at diagnosis 21\u201379 years). Group A included 64 prepubertal (aged 2.4\u201313.2 years, group A1) and 69 pubertal (aged 9.2\u201317.4, group A2) children. <i>Results:<\/i> The F:M ratio in group A was 3.0, which is significantly (p < 0.001) lower than that (10.3) found in group B patients. The F:M ratio of group A1 prepubertal children was lower (1.6) and significantly different from that of pubertal (6.7, p < 0.01) and adult patients (10.3, p < 0.0001). This phenomenon was more evident in hypothyroid as compared to euthyroid CAT. <i>Conclusions:<\/i> This study provides the first evidence that female predominance of CAT strongly increases during puberty, suggesting a major role for sex hormones in this phenomenon. Further studies are needed to clarify this point.<\/jats:p>","DOI":"10.1159\/000224341","type":"journal-article","created":{"date-parts":[[2009,7,6]],"date-time":"2009-07-06T10:41:43Z","timestamp":1246876903000},"page":"52-56","source":"Crossref","is-referenced-by-count":16,"title":["Puberty Is Associated with a Marked Increase of the Female Sex Predominance in Chronic Autoimmune Thyroiditis"],"prefix":"10.1159","volume":"72","author":[{"given":"Stefano","family":"Mariotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Prinzis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Ghiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina M.","family":"Cambuli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Pilia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Marras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Carta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Loche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fedrv-5-3-435"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.01-0998hyp"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-1366"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejhg.5201614"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2875%2980350-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0029-1211937"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.8.3779"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2400"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-1229%2882%2990204-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-0170"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-0455"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089%2F105072501316973109"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2004.056424"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.25.8.1346"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1300565"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2006.08.045"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/224341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/224341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:42:55Z","timestamp":1745448175000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000224341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000224341","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}