{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:57:41Z","timestamp":1777928261723,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"abstract":"<jats:p>Estrogen did not increase the incidence of methylcholanthrene-induced cervical squamous cell carcinomas in mice over a 48-week period. Castration decreased it significantly when compared with the estrogen treatment. This decrease was associated with lesser differentiation of the carcinomas and atrophy of the genital tract. Estrogen increased the PAS-positive material (probably neutral mucopolysaccharides) in the endometrial stroma and the acid mucopolysaccharides in the cervical subepithelial tissues. The increase of these ground substances accounted for the increase in the size of the uterus. Presence of the endometrial hyperplasias, endometrial carcinomas, mammary carcinomas and liver amyloidosis was associated with the estrogen administration. Mammary carcinomas were related also to the methylcholanthrene application to cervix and the amyloidosis of liver to the presence of carcinomas. Two spontaneously occurring ovarian neoplasms were observed.<\/jats:p>","DOI":"10.1159\/000224650","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:04:37Z","timestamp":1244214277000},"page":"33-52","source":"Crossref","is-referenced-by-count":4,"title":["Uterine and Mammary Neoplasia and other Changes (Amyloidosis) in C\n                    <sub>3<\/sub>\n                    H Mice, Related to Ovariectomy, Estrogen and Methylcholanthrene"],"prefix":"10.1159","author":[{"given":"Z.","family":"Wessely","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.V.","family":"Klavins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,5]]},"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/224650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000224650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:08:25Z","timestamp":1777676905000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000224650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000224650","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,5]]}}}