{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:07Z","timestamp":1777928527544,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:00:00Z","timestamp":1244505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:00:00Z","timestamp":1244505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"abstract":"<jats:p>Lithium carbonate (L&lt;sub&gt;i2&lt;\/sub&gt; CO&lt;sub&gt;3&lt;\/sub&gt;) increases circulating polymorphonuclear leukocytes (PMN) and perhaps granulopoiesis in man. 25 patients with advanced malignancies ingested L&lt;sub&gt;i2&lt;\/sub&gt;CO&lt;sub&gt;3&lt;\/sub&gt; during a cycle of intermittent combination chemotherapy. Weekly hemoglobin, platelet, total white blood cell (WBC) and lymphocyte counts in the evaluable patients were not significantly different from cycles before and after the L&lt;sub&gt;i2&lt;\/sub&gt;CO&lt;sub&gt;3&lt;\/sub&gt; cycles. However, the mean absolute PMN nadir while on L&lt;sub&gt;i2&lt;\/sub&gt;CO&lt;sub&gt;3&lt;\/sub&gt; was 26 % and 40 % higher than the control cycles before and after L&lt;sub&gt;i2&lt;\/sub&gt;CO&lt;sub&gt;3&lt;\/sub&gt; respectively. When compared individually, the PMN nadirs were significantly higher during the cycle with L&lt;sub&gt;i2&lt;\/sub&gt;CO&lt;sub&gt;3&lt;\/sub&gt;, than before (p = .05) or after (p = .05). The clinical and biological significance of this observation is presently unclear.<\/jats:p>","DOI":"10.1159\/000225211","type":"journal-article","created":{"date-parts":[[2009,6,10]],"date-time":"2009-06-10T13:42:04Z","timestamp":1244641324000},"page":"153-155","source":"Crossref","is-referenced-by-count":55,"title":["Effect of Lithium Carbonate on the Neutropenia Caused by Chemotherapy: A Preliminary Clinical Trial"],"prefix":"10.1159","author":[{"given":"F.A.","family":"Greco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.D.","family":"Brereton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,9]]},"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/225211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000225211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:15:16Z","timestamp":1777677316000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000225211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000225211","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,9]]}}}