{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:22:28Z","timestamp":1773282148332,"version":"3.50.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objective:<\/i> To evaluate the intraocular pressure (IOP)-lowering effects of adjunctive medications when added to 0.005% latanoprost taken once daily. <i>Methods:<\/i> Pertinent publications were identified through systematic searches of PubMed, Embase, and the Cochrane Controlled Trials Register. Randomized clinical trials with over 85% of patients presenting with primary open-angle glaucoma or ocular hypertension who were treated with the combination treatment of latanoprost were selected. The pooled additional IOP-lowering effects at 1\u20133 months after a run-in phase of at least 2 weeks on 0.005% latanoprost once daily were calculated using the random effects model. <i>Results:<\/i> Nine randomized clinical trials were included. The mean pooled IOP reductions were 3.3 mm Hg (95% CI: 2.1\u20134.5) at trough and 4.4 mm Hg (95% CI: 3.4\u20135.4) at peak when adding 0.5% timolol once daily, 2.6 mm Hg (95% CI: 1.9\u20133.3) at trough and 3.8 mm Hg (95% CI: 2.5\u20135.2) at peak when adding 0.1\/0.15% brimonidine twice daily, 2.6 mm Hg (95% CI: 1.7\u20133.4) at trough and 3.1 mm Hg (95% CI: 2.6\u20133.6) at peak when adding 2% dorzolamide twice daily, 2.4 mm Hg (95% CI: 2.0 \u20132.8) at trough and 2.7 mm Hg (95% CI: 2.2\u20133.2) at peak when adding 0.5% timolol twice daily, and 2.8 mm Hg (95% CI: 1.5\u20134.1) at trough and 1.8 mm Hg (95% CI: 1.2\u20132.3) at peak when adding 1% brinzolamide twice daily. <i>Conclusions:<\/i> The addition of brimonidine, dorzolamide, timolol, or brinzolamide can further lower IOP in eyes being treated with latanoprost. Timolol 0.5% once daily might be the most effective adjunctive medication.<\/jats:p>","DOI":"10.1159\/000225963","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T12:33:55Z","timestamp":1245674035000},"page":"99-105","source":"Crossref","is-referenced-by-count":11,"title":["Systematic Review of Intraocular Pressure-Lowering Effects of Adjunctive Medications Added to Latanoprost"],"prefix":"10.1159","volume":"42","author":[{"given":"Jin-Wei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199810293391808"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2800%2900538-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-199141040-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm00054a008"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS1350-9462%2897%2900003-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.1A178"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.85.8.983"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2801%2901177-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2802%2901827-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.survophthal.2003.12.016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.01.042"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2898%2900131-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cct.2006.04.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.315.7109.629"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2899%2900237-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-004-0135-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00061198-200402000-00014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2004.11.032"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-005-0256-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ijg.0000212240.11219.49"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000097903"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1185%2F030079908X301848"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2FIJG.0b013e31815072fe"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.38506.594977.E0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F00004397-200404420-00003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2003.018234"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.06.027"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2004.12.035"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/225963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/225963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:59:49Z","timestamp":1745449189000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000225963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000225963","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}