{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:12:10Z","timestamp":1787663530162,"version":"build-2736575974"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objective:<\/i> TNF-\u03b1 is one of the most important factors recognized in the pathogenesis of open-angle glaucoma. Therefore, the association of single nucleotide polymorphisms in the <i>TNFRI<\/i> gene and the promoter region of the <i>TNFA<\/i> gene with glaucoma susceptibility was investigated in the present study. <i>Method:<\/i> In total, 223 patients with glaucoma and 202 unrelated controls were genotyped by allele-specific oligonucleotide PCR and PCR- restriction fragment length polymorphism to determine <i>TNFA<\/i> \u2013308 G\/A and <i>TNFRI<\/i> +36 A\/G polymorphisms, respectively. <i>Results:<\/i> In contrast to <i>TNFRI<\/i> polymorphisms, the genotypes of <i>TNFA <\/i>\u2013308 G\/A polymorphisms showed a significant difference between patients and controls (p = 0.0025). Of interest, the distribution of <i>TNFA<\/i> genotypes was significantly different between patients with primary open-angle glaucoma (p = 0.001) or pseudoexfoliative glaucoma (p = 0.001) and controls, while no difference was found when chronic angle-closure glaucoma patients were compared to controls (p = 0.72). <i>Conclusion:<\/i> In line with studies showing the role of TNF-\u03b1 in open-angle glaucoma, the results of the present study showed that inheritance of the high producer <i>TNFA<\/i> \u2013308 A allele might be a susceptibility factor for the development of open-angle glaucoma.<\/jats:p>","DOI":"10.1159\/000226108","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T15:52:41Z","timestamp":1245858761000},"page":"118-124","source":"Crossref","is-referenced-by-count":21,"title":["Association of <i>TNFA<\/i> \u2013308 G\/A and <i>TNFRI<\/i> +36 A\/G Gene Polymorphisms with Glaucoma"],"prefix":"10.1159","volume":"42","author":[{"given":"Mohammad Reza","family":"Razeghinejad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feisal","family":"Rahat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskandar","family":"Kamali-Sarvestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0275-5408%2897%2900108-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-0004.1999.550201.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2801%2900799-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006%2Ftaap.1998.8406"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1098-1136%28200010%2932%3A1%3C42%3A%3AAID-GLIA40%3E3.0.CO%3B2-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.2801-06.2006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2003.10.029"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00191802"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.37.10.789"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F1.5.353"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.173.1.209"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cyto.2008.01.018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F03009740701286805"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.20055"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0079-6123%2808%2901128-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6700227"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6702078"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/226108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/226108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:01:27Z","timestamp":1745449287000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000226108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000226108","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}