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Recent experiments have shown a dominant role of the IFN-\u03b1\/\u03b2 response in protection against lethal West Nile virus (WNV) by limiting the cellular and tissue tropism of infection. This review will focus on advances in identifying the host sensors that detect WNV and the adaptor molecules and signaling pathways that regulate the induction of IFN-\u03b1\/\u03b2 defenses that limit WNV replication, spread and pathogenesis.<\/jats:p>","DOI":"10.1159\/000226248","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T12:48:03Z","timestamp":1245847683000},"page":"435-445","source":"Crossref","is-referenced-by-count":39,"title":["Measure and Countermeasure: Type I IFN (IFN-\u03b1\/\u03b2) Antiviral Response against West Nile Virus"],"prefix":"10.1159","volume":"1","author":[{"given":"Stephane","family":"Daffis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul S.","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gale, 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