{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:32:48Z","timestamp":1790854368506,"version":"4.1.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T00:00:00Z","timestamp":1246492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T00:00:00Z","timestamp":1246492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The insertion\/deletion polymorphism of the angiotensin-converting enzyme (ACE-ins\/del) and the angiotensin II type 1 receptor 1166A\/C polymorphism (ATR1166A\/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. &lt;i&gt;Objective:&lt;\/i&gt; To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. &lt;i&gt;Method:&lt;\/i&gt; Clinical data of VLBW infants were prospectively recorded. The ACE-ins\/del polymorphism and the ATR1166A\/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. &lt;i&gt;Results:&lt;\/i&gt; There was no significant association between ACE-ins\/del or ATR1166A\/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation\/necrotizing enterocolitis\/retinopathy of prematurity\/persistent ductus arteriosus. &lt;i&gt;Conclusion:&lt;\/i&gt; Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.<\/jats:p>","DOI":"10.1159\/000226602","type":"journal-article","created":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T09:21:19Z","timestamp":1246526479000},"page":"10-14","source":"Crossref","is-referenced-by-count":22,"title":["Polymorphisms in the Renin-Angiotensin System and Outcome of Very-Low-Birthweight Infants"],"prefix":"10.1159","volume":"97","author":[{"given":"J.","family":"Spiegler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gilhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vochem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"K\u00fcster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kribs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Segerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Nikischin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"von der Wense","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gebauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Herting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"G\u00f6pel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature03712"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00046106"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1113%2Fexpphysiol.2004.028456"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2FS0022-3476%2803%2900582-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.07.029"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2431-4-26"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000063092"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-3297"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000088016.67117.39"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-2670"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0006-341X.2004.00219.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000241100"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.254"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211231"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000063092"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/226602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/226602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:06:40Z","timestamp":1745449600000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000226602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,2]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000226602","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,2]]}}}