{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:10:01Z","timestamp":1745446201722,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The presence of secondary hyperparathyroidism is very frequent in the elderly population living in geriatric institutions. It has been associated with an increased mortality rate in previous studies. &lt;i&gt;Objectives:&lt;\/i&gt; To evaluate the association of secondary hyperparathyroidism with mortality or hospitalization or both (combined outcome) during a 6-month period in individuals living in geriatric institutions. &lt;i&gt;Methods:&lt;\/i&gt; A cohort of 100 individuals aged between 65 and 102 years living in geriatric institutions in the city of Porto Alegre, Brazil, was prospectively studied. Serum levels of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), albumin, total calcium, phosphorus, magnesium, creatinine and alkaline phosphatase were measured. The glomerular filtration rate (GFR) was calculated using the Cockcroft-Gault equation. Secondary hyperparathyroidism was defined as serum PTH levels higher than 48 pg\/ml and normal or reduced serum calcium levels. The deaths were verified by means of death certificates and hospitalization by the discharge summaries provided by the Brazilian health system hospitals. &lt;i&gt;Results:&lt;\/i&gt; Fifty-eight percent of the individuals had secondary hyperparathyroidism, defined as serum PTH &gt;48 pg\/ml and normal or low serum calcium. Mean serum 25(OH)D levels were 12.5 \u00b1 8 ng\/ml. The odds ratio of an individual with secondary hyperparathyroidism to die, to be hospitalized or to have the combined outcome within 6 months was 6.6 [confidence interval (CI) 95% 0.8\u201354.6; p = 0.07], 10.7 (CI 95% 1.3\u201385.9; p = 0.007) and 5.20 (CI 95% 1.10\u201327.7; p = 0.04), respectively. Secondary hyperparathyroidism and body mass index were independently associated with the combined outcome, after correction for the GFR and 25(OH)D. &lt;i&gt;Conclusion:&lt;\/i&gt; Secondary hyperparathyroidism could be an important prognostic factor for individuals living in geriatric institutions.<\/jats:p>","DOI":"10.1159\/000227760","type":"journal-article","created":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T09:21:23Z","timestamp":1246526483000},"page":"405-410","source":"Crossref","is-referenced-by-count":8,"title":["Secondary Hyperparathyroidism Is Associated with Increased Risk of Hospitalization or Death in Elderly Adults Living in a Geriatric Institution"],"prefix":"10.1159","volume":"55","author":[{"given":"Melissa Orlandin","family":"Premaor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana","family":"Scalco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Judith","family":"Souza da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Weber Furlanetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.22.4.477"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2005.02226.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00774-005-0647-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021064"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00223-007-9001-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2001.01182.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.11.4125"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2802%2900866-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pbiomolbio.2006.02.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.2007.01778.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc06-2438"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-139X.2003.160271.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00575.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000099006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2004.12.011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.29254"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000113243.24155.2F"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-0307"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1385%2FENDO%3A24%3A1%3A047"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.7.3086"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030097"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2007.01196.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.673491"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ehj.2003.09.010"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F01.hjr.0000114706.27531.01"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mehy.2004.03.041"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030515"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm289"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.061014"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11255-006-0065-7"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/227760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/227760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:33:26Z","timestamp":1745444006000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000227760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000227760","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"type":"print","value":"0304-324X"},{"type":"electronic","value":"1423-0003"}],"subject":[],"published":{"date-parts":[[2009]]}}}