{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:09:37Z","timestamp":1764331777083,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T00:00:00Z","timestamp":1247184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T00:00:00Z","timestamp":1247184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Many hemodialysis patients receive antiplatelet therapy or warfarin; however, little is known about the effect of this on iron requirements. Given the association of antiplatelet therapy with bleeding we hypothesized that there should be a greater need for iron in such patients, which we tested in this study. &lt;i&gt;Methods:&lt;\/i&gt; Retrospective 1-year cohort study of 205 chronic hemodialysis patients. The primary outcome variable was total iron dose, which was analyzed according to antiplatelet\/warfarin use. Data were also collected on potential confounders, allowing for both unadjusted and adjusted (multiple regression) analysis. &lt;i&gt;Results:&lt;\/i&gt; 97\/205 patients received antiplatelet\/warfarin therapy. This group was older, with a higher incidence of macrovascular disease and diabetes and a higher median C-reactive protein (6.0 vs. 3.75 mg\/l). Overall, median iron requirement was 1,300 mg\/year. In a multiple regression analysis, antiplatelet\/warfarin use was associated with an additional iron requirement of 703 mg (95% confidence interval 188\u20131,220 mg), with the strongest effect observed in patients with normal inflammatory markers. &lt;i&gt;Conclusion:&lt;\/i&gt; We found a high requirement for iron in patients receiving antiplatelet agents\/warfarin. We argue that the most likely mechanism for this association is chronic, low-grade blood loss, although further study is required before causality can be established.<\/jats:p>","DOI":"10.1159\/000228074","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T12:23:05Z","timestamp":1247228585000},"page":"c38-c45","source":"Crossref","is-referenced-by-count":8,"title":["Increased Iron Requirement in Hemodialysis Patients on Antiplatelet Agents or Warfarin"],"prefix":"10.1159","volume":"113","author":[{"given":"Shaun","family":"Flint","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Beavis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin J.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenie","family":"Pedagogos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2005.10.039"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.01810407"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.06.017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1797.2006.00647.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1797.2005.00466.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2000.8275"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-139X.2006.00124.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00225.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2005.02649.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.07.007"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:36:54Z","timestamp":1745444214000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,10]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228074","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2009,7,10]]}}}