{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:20:23Z","timestamp":1791188423850,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; A previous limited study showed promising results of combined oral treatment with rifampicin 600 mg and clindamycin 600 mg for 10 weeks. &lt;i&gt;Objective:&lt;\/i&gt; To expand and to validate the basis for this therapy, we reviewed the response to different treatment durations. &lt;i&gt;Method:&lt;\/i&gt; A retrospective study in 34 patients. &lt;i&gt;Results:&lt;\/i&gt; Twenty-eight of 34 patients (82%) experienced at least partial improvement, and 16 (47%) showed a total remission. The maximum effect of treatment appeared within 10 weeks. Following total remission, 8 of 13 (61.5%) patients treated as mentioned above experienced a relapse after a mean period of 5.0 months. Nonresponders were predominantly patients with severe disease. &lt;i&gt;Conclusion:&lt;\/i&gt; Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. The length and the dosage of treatment are not yet firmly established.<\/jats:p>","DOI":"10.1159\/000228337","type":"journal-article","created":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T14:38:56Z","timestamp":1246977536000},"page":"143-147","source":"Crossref","is-referenced-by-count":185,"title":["The Effect of Combined Treatment with Oral Clindamycin and Oral Rifampicin in Patients with Hidradenitis Suppurativa"],"prefix":"10.1159","volume":"219","author":[{"given":"Hessel H.","family":"van der Zee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurr","family":"Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol P.","family":"Prens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B.E.","family":"Jemec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.06.020"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.08.061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2001.04137.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1996.tb03880.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2896%2990277-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000246246"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1999.02613.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000096194"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1983.tb02150.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970272-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2880%2992081-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2001.00746.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1999.02675.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2006.07155.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000228334"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.2005.01983.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F09546630600830588"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2002.11125.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08735.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01743360"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0738-081X%2802%2900328-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0065-2164%2804%2956004-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1086%2F426545"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0163-4453%2893%2995367-R"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:40:00Z","timestamp":1745444400000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228337","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}