{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:10:22Z","timestamp":1773421822037,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; An endothelial dysfunction has been described in autosomal dominant polycystic kidney disease (ADPKD) before the development of hypertension and renal impairment. The aim of this work was to verify the existence of a microvascular reactivity in the early stages of ADPKD. &lt;i&gt;Methods:&lt;\/i&gt; Fifteen ADPKD normotensive patients with normal renal function underwent laser Doppler examination of the cutaneous microcirculation in basal conditions and after the warm test, as well as evaluation of plasma concentrations of some endothelial activation parameters [total cholesterol and fractions, fibrinogen, von Willebrand factor, Lp(a)]. The results were compared with those in 15 healthy subjects, 15 essential hypertensive patients and 15 hypertensive ADPKD patients with normal renal function. &lt;i&gt;Results:&lt;\/i&gt; Both basal and post-warm-test values were significantly lower in normotensive ADPKD subjects than controls (3.2 \u00b1 1 vs. 5.8 \u00b1 1.3 AU, p = 0.0001; 35.2 \u00b1 10.9 vs. 50.5 \u00b1 10.8 AU, p = 0.005, respectively). All evaluated parameters were within normal limits and comparable between normotensive ADPKD subjects and controls, except for LDL cholesterol (125 \u00b1 18 vs. 101 \u00b1 22 mg\/dl, p = 0.01) and Lp(a), which was significantly higher in the ADPKD subjects (52.2 \u00b1 36 vs. 6.0 \u00b14 mg\/dl, p = 0.0006). &lt;i&gt;Conclusion:&lt;\/i&gt; Our study confirms the existence of a systemic microcirculation defect in ADPKD. The presence of high levels of Lp(a) could contribute to causing the high incidence of cardiovascular events in ADPKD.<\/jats:p>","DOI":"10.1159\/000228537","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T06:30:36Z","timestamp":1247553036000},"page":"c71-c75","source":"Crossref","is-referenced-by-count":8,"title":["Cutaneous Microcirculation Is Impaired in Early Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.1159","volume":"113","author":[{"given":"Alfonso","family":"Ramunni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Brescia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Quaranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Stella","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prudenza","family":"Ranieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesta","family":"Dolce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Coratelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2004.01.011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2902663-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000102971.85504.7c"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg080"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000051257"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199010183231602"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2898%2970071-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra022161"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.12.6397"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.040550097"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00236.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00913.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000025404.78001.D8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000012543.55874.47"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199901143400207"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0702.103727"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.00287.2004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001511"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0026-2862%2803%2900006-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080%2F08037050600996586"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.27.221"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2897%2900497-X"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2896%2900159-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2898%2900954-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F00019501-199201000-00008"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:42:14Z","timestamp":1745444534000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,14]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228537","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,14]]}}}