{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:15:51Z","timestamp":1779084951013,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Hemodialysis patients are prone to ischemic events potentially aggravated by hypoxia. The key player in adaptation to hypoxia is hypoxia-inducible factor-1 alpha (HIF-1\u03b1). Therefore, we investigated the association of HIF-1\u03b1 polymorphisms with ischemia\/hypoxia-related events in hemodialysis patients. &lt;i&gt;Methods:&lt;\/i&gt; Patients on maintenance hemodialysis were enrolled from 4 training hospitals in Korea. Seven single nucleotide polymorphisms (SNP) of HIF-1\u03b1 were genotyped. The association of these SNP with hypoxia-related clinical outcomes (ischemic diseases and anemia) and cancer was analyzed. &lt;i&gt;Results:&lt;\/i&gt; A total of 376 patients participated in the study. No significant difference in genotype distribution was found between subjects with and without the hypoxia-related events. Three sets of linkage disequilibrium blocks were made for haplotype analyses (rs2783778 and rs7148720 in 5\u2032 upstream region; rs7143164 and rs10873142; rs2301113, rs11549465 and rs2057482). Of these, the CT haplotype in the first set was associated with both acute myocardial infarction and frequent intradialytic hypotension (acute myocardial infarction: adjusted odds ratio = 0.15, 95% CI: 0.03\u20130.69; frequent intradialytic hypotension: adjusted odds ratio = 0.29, 95% CI: 0.12\u20130.72). &lt;i&gt;Conclusion:&lt;\/i&gt; Genetic polymorphisms of HIF-1\u03b1 were associated with acute myocardial infarction and intradialytic hypotension in hemodialysis patients.<\/jats:p>","DOI":"10.1159\/000228542","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T06:30:36Z","timestamp":1247553036000},"page":"c104-c111","source":"Crossref","is-referenced-by-count":20,"title":["Genetic Polymorphisms of Hypoxia-Inducible Factor-1 Alpha and Cardiovascular Disease in Hemodialysis Patients"],"prefix":"10.1159","volume":"113","author":[{"given":"Zhen Lon","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hwan","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Kyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sejoong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Ro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Ah","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Kyung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwon Wook","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeseok","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Frmed.2002.1346"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1124%2Fmol.106.027029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature06905"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00109-007-0278-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2007.07.042"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-0991"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.joca.2006.12.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2004.01.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000088"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086%2F519795"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.914801"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2005.08.045"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2006.114033"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1091%2Fmbc.E07-04-0391"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa073123"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:42:19Z","timestamp":1745444539000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,14]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228542","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,14]]}}}