{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:15:31Z","timestamp":1761894931307,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objective:<\/i> Niacin is underutilized due to flushing, which occurs in over 90% of niacin-treated patients. Laropiprant (LRPT) reduces flushing associated with niacin. This study compared flushing with a combination tablet of extended-release (ER) niacin (ERN)\/LRPT to niacin ER (N-ER; without LRPT) during the first week of therapy among patients in Asia. <i>Methods:<\/i> Following a 1-week placebo run-in, 332 patients with dyslipidemia from China, Korea and Singapore were randomized to ERN\/LRPT 1 g\/20 mg, N-ER 1 g (given as Niaspan\u00ae) or placebo in a 2:2:1 ratio for 1 week. Patient-reported flushing severity was assessed using the Global Flushing Severity Score (GFSS; none\/mild = 0\u20133; moderate = 4\u20136; severe = 7\u20139; extreme = 10). <i>Results:<\/i> Compared with N-ER, the ERN\/LRPT group experienced significantly less flushing (p < 0.001), as measured by maximum GFSS categorized as none\/mild, moderate, severe or extreme. Overall, 23.8% of patients in the ERN\/LRPT group and 50.0% in the N-ER group (p < 0.001), versus 12.1% in the placebo group, had moderate or greater flushing (GFSS \u22654). Except for flushing, which occurred more frequently in the N-ER group, ERN\/LRPT had a safety\/tolerability profile similar to that of N-ER. <i>Conclusion:<\/i> ERN\/LRPT produced significantly less flushing than N-ER during the initiation of therapy and was generally well tolerated in Asian patients with dyslipidemia.<\/jats:p>","DOI":"10.1159\/000228585","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T13:29:55Z","timestamp":1247664595000},"page":"192-198","source":"Crossref","is-referenced-by-count":11,"title":["Flushing Profile of Extended-Release Niacin\/Laropiprant at Initiation of Therapy in Asian Lipid Clinic Patients"],"prefix":"10.1159","volume":"114","author":[{"given":"Debra","family":"Kush","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erluo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waheeda","family":"Sirah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"McCrary Sisk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Paolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darbie","family":"Maccubbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011090"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2897%2900303-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2886%2980293-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.231.4.360"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0026-0495%2885%2990092-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2898%2900731-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2898%2900732-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.154.14.1586"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186%2F1472-6904-3-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2006.08.063"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0601574103"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm0603668"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2007.10.023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1742-1241.2008.01938.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1185%2F030079907X199637"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1185%2F03007990802083408"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:42:42Z","timestamp":1745444562000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228585","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2009]]}}}