{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:06Z","timestamp":1783948806984,"version":"3.55.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. &lt;i&gt;Methods:&lt;\/i&gt; Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport\u00ae). The primary endpoint was reduction in number of migraine attacks up to week 8 and between weeks 8 and 12 after injection. Patient diaries were used to record secondary endpoints, including frequency, severity and duration of migraine attacks. &lt;i&gt;Results:&lt;\/i&gt; There was a mean reduction of 0.54 and 0.94 attacks\/month with placebo and BoNT-A, respectively, and absolute attack count was less in the verum group (3.6 vs. 4.2 attacks\/month), but this was not statistically significant. The patients\u2019 global assessment of efficacy was significantly better than placebo in the high-dose group (p = 0.02) but no effects were seen for the other secondary efficacy parameters. &lt;i&gt;Conclusion:&lt;\/i&gt; Our study showed a trend towards a reduced attack rate with verum but did not show any statistically significant efficacy of BoNT-A in the prophylactic treatment of migraine.<\/jats:p>","DOI":"10.1159\/000228987","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T11:58:19Z","timestamp":1248091099000},"page":"204-211","source":"Crossref","is-referenced-by-count":30,"title":["Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study"],"prefix":"10.1159","volume":"62","author":[{"given":"Susanne","family":"Petri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"T\u00f6lle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Straube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Pfaffenrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Stefenelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Ceballos-Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410280407"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4598%28199811%2921%3A11%3C1540%3A%3AAID-MUS27%3E3.0.CO%3B2-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200102153440704"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.med.55.091902.104440"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs101940300003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4610.2006.00712.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-2982.2000.020004332.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-4610.2000.00066.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-2982.2000.020004421.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-2982.2004.00754.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.20066"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4610.1981.hed2102049.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-2982.2000.00117.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2307%2F2288413"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4610.2007.00853.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4637.2006.00168.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-007-0832-3"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:47:33Z","timestamp":1745444853000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228987","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}