{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:30:33Z","timestamp":1758814233684,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Chronic administration of glucocorticosteroids (GCs) can have significant catabolic effects in vivo in a host of metabolic systems, including amino acid metabolism, skeletal muscle, bone and linear growth. GCs inhibit protein synthesis and increase protein breakdown at the skeletal muscle and whole-body level and impair growth hormone (GH) secretion and action. Conversely, GH and insulin-like growth factor I (IGF-I) are potent protein-anabolic and growth-promoting agents in vitro and in vivo. This review summarizes both the catabolic effects of GCs and the anabolic and metabolic effects of GH and IGF-I. &lt;i&gt;Conclusions:&lt;\/i&gt; Both GH and IGF-I may decrease the catabolic effects of chronic steroid use in humans, particularly by enhancing lean body mass accrual and, in children, by increasing linear growth.<\/jats:p>","DOI":"10.1159\/000229764","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T21:32:47Z","timestamp":1259357567000},"page":"48-54","source":"Crossref","is-referenced-by-count":10,"title":["Can Growth Hormone Counteract the Catabolic Effects of Steroids?"],"prefix":"10.1159","volume":"72","author":[{"given":"Nelly","family":"Mauras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1677%2FJOE-07-0606"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ghir.2003.12.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F35016611"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119438"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ghir.2004.12.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.4.1686"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ghir.2007.04.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116212"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.9.2633"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.9.3036"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.9.3115"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2906467-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-5793%2886%2980856-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199910143411607"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.2.382"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2894%2900512-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.15.6983"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-69-6-1274"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2000.105369"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.4.1496"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-67-6-1258"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-72-3-675"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1770381"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114694"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.40.1.141"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.3.869"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.1999.14.5.710"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2004.07.015"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2002.28972"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200003233421204"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-031409"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1101"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2877"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/229764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/229764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:57:02Z","timestamp":1745445422000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000229764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":33,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000229764","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2009]]}}}