{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:30:54Z","timestamp":1790663454267,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>We tested the hypothesis whether the partially duplicated variant of \u03b17 nicotinic acetylcholine receptor subunit gene (CHRFAM7A) 2-bp deletion (\u20132 bp) polymorphism and apolipoprotein E (ApoE) \u03b54 allele confer susceptibility to Alzheimer\u2019s disease (AD), dementia with Lewy bodies (DLB), Pick\u2019s disease (PiD) and vascular dementia (VD). The study included 175 AD, 35 DLB patients, 38 PiD, 96 VD and 175 healthy control (HC) probands. The CHRFAM7A genotype without the \u20132 bp allele was significantly over-represented in AD (p = 0.011), DLB (p = 0.001) and PiD (p &lt; 0.0001) compared to HC, but there were no statistical differences in VD (p = 0.407) compared to HC. We confirmed again that the ApoE \u03b54 allele is a risk factor for dementias. The \u20132 bp polymorphism of CHRFAM7A can be implicated in AD, DLB and PiD. However, it is unlikely that it plays an important role in the pathogenesis of VD.<\/jats:p>","DOI":"10.1159\/000230036","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T13:44:38Z","timestamp":1248875078000},"page":"56-62","source":"Crossref","is-referenced-by-count":33,"title":["Association between a Genetic Variant of the Alpha-7 Nicotinic Acetylcholine Receptor Subunit and Four Types of Dementia"],"prefix":"10.1159","volume":"28","author":[{"given":"\u00c1gnes","family":"Feh\u00e9r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Riman\u00f3czy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Csibri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Janka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.57.4.416"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-4328%2800%2900199-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.275.8.5626"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M212532200"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1998.5363"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.2002.6694"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fejhg.2008.112"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1582-4934.2001.tb00159.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0600549103"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.JGP.0000225088.29353.08"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2800%2900150-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000051273"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1997.tb00069.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-0327%2800%2900292-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopsych.2006.03.054"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1998.tb07288.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj%2Fmp%2F4000916"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11064-005-2745-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000095246"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.63.3.431"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.57.11.1414"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-002-0751-2"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:59:54Z","timestamp":1745445594000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000230036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000230036","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}