{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:46:09Z","timestamp":1764510369462,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>The &lt;i&gt;BCR-ABL&lt;\/i&gt; fusion gene represents the hallmark of chronic myelogenous leukemia (CML) and is derived from a translocation between chromosome 9 and 22. The majority of CML patients have a breakpoint in the major &lt;i&gt;BCR&lt;\/i&gt; region of the &lt;i&gt;BCR&lt;\/i&gt; gene giving rise to e13a2 or e14a2 &lt;i&gt;BCR-ABL&lt;\/i&gt; transcripts. Occasionally, other &lt;i&gt;BCR&lt;\/i&gt; breakpoints occur. The current report describes two e6a2 CML patients with imatinib treatment failure and unusual disease progression. One patient was Philadelphia chromosome positive and one was Philadelphia chromosome negative with an atypical &lt;i&gt;BCR-ABL&lt;\/i&gt; rearrangement, ins (22;9).<\/jats:p>","DOI":"10.1159\/000230037","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T13:44:38Z","timestamp":1248875078000},"page":"11-16","source":"Crossref","is-referenced-by-count":9,"title":["Chronic Myelogenous Leukemia with the e6a2 &lt;i&gt;BCR-ABL&lt;\/i&gt; and Lacking Imatinib Response: Presentation of Two Cases"],"prefix":"10.1159","volume":"122","author":[{"given":"Hege K.","family":"Vefring","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz X.E.","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line","family":"Wee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi","family":"Hovland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hjorth-Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Gedde Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F315758a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403079"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404949"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190500138138"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403476"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2401916"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.leukres.2007.05.022"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190701216402"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403136"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404792"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa062867"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403135"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000094686"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2402741"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403595"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:59:54Z","timestamp":1745445594000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000230037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000230037","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2009]]}}}