{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:57:22Z","timestamp":1777899442365,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:00:00Z","timestamp":1248134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:00:00Z","timestamp":1248134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>The course of anaphylaxis has been studied in guinea pigs passively sensitized by the injection of guinea-pig antibody to egg albumin. A variety of conditions were used for sensitization and for each condition the effect of an anti-histamine (mepyramine) was measured. Reduction in the amount of antiserum used led to a corresponding reduction in the severity of anaphylaxis but little change was found when the amount of antigen was altered over a 50-fold range. A considerable proportion of the anaphylactic response was resistant to anti-histamine treatment. A small part of the antibody was heat-stable but most of it was persistent for at least 10 days. \u03b2-adrenergic blockade increased the anaphylactic response and animals so treated were refractory to anti-histamine treatment.<\/jats:p>","DOI":"10.1159\/000230557","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"648-654","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative Studies on Anaphylaxis in Guinea-Pigs Passively Sensitized with Homologous Antibody"],"prefix":"10.1159","author":[{"given":"G.E.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.P.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,21]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000230557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:02:25Z","timestamp":1777629745000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000230557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000230557","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,21]]}}}