{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:12:30Z","timestamp":1760955150322,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In hemodialysis (HD) patients, the plasma brain natriuretic peptide (BNP) level is associated with left ventricular dysfunction and patients\u2019 survival. Malnutrition is common in HD patients, it is associated with inflammation and contributes to the high incidence of cardiovascular (CV) disease in this setting (malnutrition-inflammation-atherosclerosis syndrome). In a cross-sectional study, we assessed the relationship between predialysis plasma BNP level and nutritional markers in chronic HD patients. &lt;i&gt;Methods:&lt;\/i&gt; Of 210 patients receiving HD treatment in our unit, 51 patients who were treated with three times weekly long-hour HD (5\u20138 h\/session) for at least 6 months (mean age 65.8 \u00b1 15.0 years; F\/M ratio 23\/28; vintage 71.3 \u00b1 71.9 months; BMI 24.9 \u00b1 5.9; session time 6.9 \u00b1 1.3 h; percentage of diabetic patients 31%) were studied before a mid-week HD session for nutritional markers (plasma albumin 35.3 \u00b1 3.7 g\/l; prealbumin 0.36 \u00b1 0.09 g\/l; CRP 15.3 \u00b1 14.7 mg\/l; nPNA 1.29 \u00b1 0.29 g\/kg\/day) and plasma BNP (246.9 \u00b1 252.2 ng\/l, normal &lt;100 ng\/l, Bayer\u00ae kit). The interdialytic weight gain was 2.1 \u00b1 1.0 kg. In the last 3 months prior to the commencement of the study, the patients\u2019 dry weight varied by +0.17 \u00b1 1.9 kg. &lt;i&gt;Results:&lt;\/i&gt; Predialysis plasma BNP levels did not differ according to gender and the presence of diabetes. It was not correlated with age and vintage but was found to be negatively associated with the session time (r = \u20130.34, p = 0.018). Several nutritional markers were negatively correlated with BNP levels: prealbumin (r = \u20130.46, p = 0.001), BMI (r = \u20130.33, p = 0.018), nPNA (r = \u20130.46, p = 0.002). The plasma albumin relationship with the BNP level was close to significance (p = \u20130.26, p = 0.070). The 3-month dry weight variation was also negatively correlated with BNP levels (r = \u20130.34, p = 0.018). With multiple stepwise regression analysis, prealbumin and session time remained significant (respectively p = 0.004 and 0.01). BNP levels were higher in a subgroup of malnourished patients (n = 12) (400 \u00b1 405 vs. 202 \u00b1 166 ng\/l, p = 0.03) than in patients who did not meet the malnutrition criteria (34 patients). They were not correlated with CRP levels, interdialytic weight gain, or predialysis MAP. &lt;i&gt;Conclusions:&lt;\/i&gt; Hence, the plasma BNP level was found to be associated with malnutrition but not with inflammation. This underlines the relationship between nutrition and the CV system in HD patients. The body weight variations associated with malnutrition and the difficulties in assessing and adjusting dry weight may lead to fluid overload, which could explain, in part, these correlations.<\/jats:p>","DOI":"10.1159\/000230809","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T11:27:44Z","timestamp":1249039664000},"page":"187-192","source":"Crossref","is-referenced-by-count":10,"title":["The Plasma Level of Brain Natriuretic Peptide Is Increased in Malnourished Hemodialysis Patients"],"prefix":"10.1159","volume":"28","author":[{"given":"Charles","family":"Chazot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Jean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Vo-Van","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Collonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Claude","family":"Terrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Vanel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie","family":"Lorriaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marc","family":"Hurot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Charra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00422.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00338.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-199404000-00001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg371"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00616.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000073669"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4065%2F76.11.1111"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2003.028712"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000079170"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000110564"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2002.36329"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:04:12Z","timestamp":1745445852000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000230809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000230809","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2009]]}}}