{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:58:41Z","timestamp":1777899521571,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>The course of production and some properties of homocytotropic antibodies produced in guinea-pigs after infection with Trichinella spiralis have been examined by the PCA reaction using whole sera and \u03b3-globulin fractions prepared by DEAE cellulose gradient chromatography. Two heat-stable homocytotropic antibodies eluting in the \u03b3&lt;sub&gt;1&lt;\/sub&gt;region have been identified; these differ markedly in their capacity to persist in the skin. In addition a heat-labile (56\u00b0C\/30 min) antibody, which can elicit PCA reactions 21 days after sensitization, was found as a minor component in several fractions. The reagin-like antibody appeared in detectable amounts in serum for a limited period after a single infection (days 25\u201345). The heat-stable homocytotropic antibodies were first demonstrated in the 2nd or 3rd week of infection and were produced together for an extensive period. There is evidence that reagin-like antibody competes for sensitization sites in the skin and partially inhibits sensitization by \u03b3&lt;sub&gt;1&lt;\/sub&gt;heat-stable antibodies.<\/jats:p>","DOI":"10.1159\/000230852","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"371-382","source":"Crossref","is-referenced-by-count":7,"title":["Homocytotropic Antibodies in the Guinea-Pig"],"prefix":"10.1159","author":[{"given":"D.","family":"Catty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.F.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/230852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000230852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:05:37Z","timestamp":1777629937000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000230852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000230852","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}