{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:00:12Z","timestamp":1777899612748,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>(1) Following the onset of sensitivity to picric acid (PA) by means of a \u2018split-adjuvant\u2019 technique, an anamnestic rise in the degree of sensitivity occurs accompanied by a qualitative change in the lymphoid cells, confirmed in cellular transfer experiments. (2) Animals sensitized with PA respond to picryl chloride (PCI) in contact, not in intradermal tests, and fail to respond to picrylated protein in intradermal tests. Animals rendered tolerant to PA cannot, as expected, be sensitized with PA and after attempted sensitization with PA failed to show any recognition of PCI; PCl-tolerant animals sensitized with PA divide into two populations, non-responders and responders. Possibly different \u2018carrier\u2019 structures are utilized in epicutaneous and in intradermal sensitizations. (3) A special sensitizing procedure (Ikuta) leads to the appearance of (a) anti-\u2019picric\u2019 (passive cutaneous anaphylaxis) antibodies, and (b) delayed hypersensitivity to intradermal PA without contactant-type sensitivity to PA. The delayed-type hypersensitivity is transferable by cells, but again only intradermal, not contactant, hypersensitivity has been noted, indicating that these two delayed-type responses may be dissociable. The anti-\u2019picric\u2019 antibodies differ from anti-picryl antibodies and require a 2-step eliciting technique to secure passive cutaneous anaphylaxis.<\/jats:p>","DOI":"10.1159\/000231098","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"513-542","source":"Crossref","is-referenced-by-count":10,"title":["Studies on the Sensitization of Animals with Simple Chemical Compounds"],"prefix":"10.1159","author":[{"given":"Merrill W.","family":"Chase","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Maguire, jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:08:56Z","timestamp":1777630136000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231098","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}