{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:00:27Z","timestamp":1777899627886,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>A fraction of synthetic linear dextran (D-8) of Mn 26,900 was tested for cross-reactivity with rabbit anti-B512 dextran antiserum (RAD) and compared to a B512 dextran fraction (D-40) of similar molecular weight distribution. B512 dextran is a linear \u03b1-1\u20136 linked polyglucose with few side chains: about one branch per 20 glucose units; at least 80% of branches comprise only 1\u20132 glucose residues. The synthetic dextran is a completely linear \u03b1-1\u20136 linked polyglucose. In Ouchterlony gel double-diffusion, both D-8 and D-40 produced single precipitate lines; in a comparative array, complete fusion of precipitate lines of D-8 and D-40 indicated the identity of antigenic determinants. In quantitative precipitation and single radial immunodiffusion, D-8 and D-40 precipitated comparable amounts of antidextrans and produced precipitate haloes of similar size. Systemic lethal anaphylaxis could be elicited by D-8 in passively sensitized guinea pigs, and protection from lethal shock was obtained by adding isomaltooctaose to D-8 upon challenge. Similarly, passive cutaneous anaphylaxis (PCA) of comparable intensity was elicited by D-8 and D-40 upon challenge of sensitized guinea pigs. Neutralization of PCA by adding D-8 to RAD prior to intradermal sensitization and challenge with D-40 also indicated the identity of antigenic determinants. These findings are taken as evidence that D-8 is a homodeterminant antigen with many determinants, and that the antigenic determinants of both linear synthetic and B512 dextran are repetitively arranged along the molecular chain.<\/jats:p>","DOI":"10.1159\/000231147","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"438-447","source":"Crossref","is-referenced-by-count":20,"title":["Cross-Reactivity of Synthetic Linear Dextran with Anti-B512 Dextran"],"prefix":"10.1159","author":[{"given":"Wolfgang","family":"Richter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:09:37Z","timestamp":1777630177000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231147","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}